This gene encodes a member of the serine/threonine protein kinase family. The encoded protein is a membrane-associated kinase that negatively regulates the G2/M transition of the cell cycle by phosphorylating and inactivating cyclin-dependent kinase 1. The activity of the encoded protein is regulated by polo-like kinase 1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012].
Dai, Yamasaki, Yang, Sayama, Shirakata, Tokumara, Yahata, Tohyama, Hashimoto: "Keratinocyte G2/M growth arrest by 1,25-dihydroxyvitamin D3 is caused by Cdc2 phosphorylation through Wee1 and Myt1 regulation." in: The Journal of investigative dermatology, Vol. 122, Issue 6, pp. 1356-64, (2004) (PubMed).
Passer, Nancy-Portebois, Amzallag, Prieur, Cans, Roborel de Climens, Fiucci, Bouvard, Tuynder, Susini, Morchoisne, Crible, Lespagnol, Dausset, Oren, Amson, Telerman: "The p53-inducible TSAP6 gene product regulates apoptosis and the cell cycle and interacts with Nix and the Myt1 kinase." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, Issue 5, pp. 2284-9, (2003) (PubMed).
Nakajima, Toyoshima-Morimoto, Taniguchi, Nishida: "Identification of a consensus motif for Plk (Polo-like kinase) phosphorylation reveals Myt1 as a Plk1 substrate." in: The Journal of biological chemistry, Vol. 278, Issue 28, pp. 25277-80, (2003) (PubMed).
Aliases for PKMYT1 抗体
protein kinase, membrane associated tyrosine/threonine 1 (PKMYT1) 抗体 protein kinase, membrane associated tyrosine/threonine 1 (pkmyt1) 抗体 protein kinase, membrane associated tyrosine/threonine 1 (Pkmyt1) 抗体 protein kinase, membrane associated tyrosine/threonine 1 S homeolog (pkmyt1.S) 抗体 6230424P17 抗体 AW209059 抗体 MYT1 抗体 Myt1 抗体 myt1 抗体 RGD1305434 抗体