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PKC iota 产品

(Protein Kinase C, iota (PRKCI))
This gene encodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases. The PKC family comprises at least eight members, which are differentially expressed and are involved in a wide variety of cellular processes. This protein kinase is calcium-independent and phospholipid-dependent. It is not activated by phorbolesters or diacylglycerol. This kinase can be recruited to vesicle tubular clusters (VTCs) by direct interaction with the small GTPase RAB2, where this kinase phosphorylates glyceraldehyde-3-phosphate dehydrogenase (GAPD/GAPDH) and plays a role in microtubule dynamics in the early secretory pathway. This kinase is found to be necessary for BCL-ABL-mediated resistance to drug-induced apoptosis and therefore protects leukemia cells against drug-induced apoptosis. There is a single exon pseudogene mapped on chromosome X. [provided by RefSeq, Jul 2008].

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Featured PKC iota Categories

PKC iota 抗体

High quality antibodies with extensive validation data.

PKC iota ELISA试剂盒

Reliable ELISA kits for a wide range of species.

PKC iota 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended PKC iota 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IHC, IP, ICC
Validations
  • (6)
Cat. No. ABIN7444109
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IF, RNAi
Validations
  • (5)
Cat. No. ABIN562391
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Mouse
Application WB, ELISA, IHC (p)
Validations
  • (3)
  • (3)
Cat. No. ABIN545464
Quantity 400 μL
Datasheet Datasheet

Recommended PKC iota ELISA试剂盒

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN1116783
Quantity 96 tests
Datasheet Datasheet
Reactivity Rat
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN1116784
Quantity 96 tests
Datasheet Datasheet
Reactivity Chicken
Analytical Method
Validations
Cat. No. ABIN1057780
Quantity 96 tests
Datasheet Datasheet

Recommended PKC iota 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (2)
Cat. No. ABIN1316270
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1316272
Quantity 10 μg
Datasheet Datasheet
Reactivity Mouse
Source Insect Cells
Validations
Cat. No. ABIN3135495
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our PKC iota Products

Nanos-Webb, Bui, Karakas, Zhang, Carey, Mills, Hunt, Keyomarsi: "PKCiota promotes ovarian tumor progression through deregulation of cyclin E." in: Oncogene, Vol. 35, Issue 19, pp. 2428-40, (2016) (PubMed).

Qu, Li, Xia, Hongdu, Xu, Lin, Chen: "PRKCI negatively regulates autophagy via PIK3CA/AKT-MTOR signaling." in: Biochemical and biophysical research communications, Vol. 470, Issue 2, pp. 306-12, (2016) (PubMed).

Lechuga, Baranwal, Ivanov: "Actin-interacting protein 1 controls assembly and permeability of intestinal epithelial apical junctions." in: American journal of physiology. Gastrointestinal and liver physiology, Vol. 308, Issue 9, pp. G745-56, (2015) (PubMed).

Forteza, Wald, Mashukova, Kozhekbaeva, Salas: "Par-complex aPKC and Par3 cross-talk with innate immunity NF-κB pathway in epithelial cells." in: Biology open, Vol. 2, Issue 11, pp. 1264-9, (2013) (PubMed).

Wang, Li, Du, Lu, Zou: "Significance and expression of atypical protein kinase C-iota in human hepatocellular carcinoma." in: The Journal of surgical research, Vol. 154, Issue 1, pp. 143-9, (2009) (PubMed).

Li, Wang, Liu, Xiao, Lu, Zou: "Correlation of aPKC-iota and E-cadherin expression with invasion and prognosis of cholangiocarcinoma." in: Hepatobiliary & pancreatic diseases international : HBPD INT, Vol. 7, Issue 1, pp. 70-5, (2008) (PubMed).

Wald, Oriolo, Mashukova, Fregien, Langshaw, Salas: "Atypical protein kinase C (iota) activates ezrin in the apical domain of intestinal epithelial cells." in: Journal of cell science, Vol. 121, Issue Pt 5, pp. 644-54, (2008) (PubMed).

Guo, Wu, Liu, Fang: "Identification of a small molecule with synthetic lethality for K-ras and protein kinase C iota." in: Cancer research, Vol. 68, Issue 18, pp. 7403-8, (2008) (PubMed).

Pu, Peach, Garfield, Wincovitch, Marquez, Blumberg: "Effects on ligand interaction and membrane translocation of the positively charged arginine residues situated along the C1 domain binding cleft in the atypical protein kinase C isoforms." in: The Journal of biological chemistry, Vol. 281, Issue 44, pp. 33773-88, (2006) (PubMed).

Zhang, Anastasiadis, Liu, Thompson, Fields: "Protein kinase C (PKC) betaII induces cell invasion through a Ras/Mek-, PKC iota/Rac 1-dependent signaling pathway." in: The Journal of biological chemistry, Vol. 279, Issue 21, pp. 22118-23, (2004) (PubMed).

Synonyms and alternative names related to PKC iota

protein kinase C iota (PRKCI), protein kinase C, iota (prkci), protein kinase C, iota (Prkci), protein kinase C iota (Prkci), 2310021H13Rik, AI427505, aPKClambda, aPKC[l], DXS1179E, hal, has, mKIAA4165, nPKC-iota, PKC, PKCI, Pkci, Pkcl, PKClambda, PRKCI, Prkcl

Protein level used designations for PKC iota

  • PRKC-lambda/iota
  • aPKC-lambda/iota
  • atypical protein kinase C-lambda/iota
  • protein kinase C iota type
  • heart and soul protein
  • nPKC-iota
  • protein kinase C, iota
  • protein kinase C iota
  • protein kinase C, lambda
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