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Mouse (Murine) Polyclonal PPP2CA Primary Antibody for WB - ABIN1881681
Pradhan, Alrehani, Patel, Khatlani, Vijayan: Cross-talk between serine/threonine protein phosphatase 2A and protein tyrosine phosphatase 1B regulates Src activation and adhesion of integrin αIIbβ3 to fibrinogen. in The Journal of biological chemistry 2010
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Monoclonal PPP2CA Primary Antibody for IP, WB - ABIN534113
Kumamoto: A contact-activated kinase signals Candida albicans invasive growth and biofilm development. in Proceedings of the National Academy of Sciences of the United States of America 2005
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Human Monoclonal PPP2CA Primary Antibody for IP, WB - ABIN1042658
Sontag, Nunbhakdi-Craig, Sontag, Diaz-Arrastia, Ogris, Dayal, Lentz, Arning, Bottiglieri: Protein phosphatase 2A methyltransferase links homocysteine metabolism with tau and amyloid precursor protein regulation. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2007
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Human Polyclonal PPP2CA Primary Antibody for IP, WB - ABIN151684
Yamamoto, Blake-Hodek, Williams, Lewellyn, Goldberg, Maller: Regulation of Greatwall kinase during Xenopus oocyte maturation. in Molecular biology of the cell 2011
Human Polyclonal PPP2CA Primary Antibody for ELISA, WB - ABIN257667
Hemmings, Wernet, Mayer, Maurer, Hofsteenge, Stone: The nucleotide sequence of the cDNA encoding the human lung protein phosphatase 2A beta catalytic subunit. in Nucleic acids research 1989
Human Polyclonal PPP2CA Primary Antibody for WB - ABIN363066
Yu, Du, Moreno, Green, Ogris, Feng, Chou, McQuoid, Pallas: Methylation of the protein phosphatase 2A catalytic subunit is essential for association of Balpha regulatory subunit but not SG2NA, striatin, or polyomavirus middle tumor antigen. in Molecular biology of the cell 2001
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Human Polyclonal PPP2CA Primary Antibody for WB - ABIN1842544
Wu, Reardon, Storey: Effects of hibernation on regulation of mammalian protein phosphatase type-2-A. in Cryobiology 2013
In vitro, SCF (显示 KITLG 抗体) induced the phosphorylation of p38 MAPK (显示 MAPK14 抗体) and cofilin (显示 CFL1 抗体), leading to the migration of cardiac stem cells.
We describe a novel mechanism of signal transduction enriched in medium spiny neurons of striatum that likely mediates effects of the neurotransmitter dopamine acting on these cells. We find that the protein ARPP-16, which is highly expressed in striatal medium spiny neurons, acts as a selective inhibitor of certain forms of the serine/threonine protein phosphatase, PP2A, when phosphorylated by the kinase, MAST3.
data show that Fyn (显示 FYN 抗体) kinase is activated after TLR4 (显示 TLR4 抗体) triggering and exerts an important negative control on LPS (显示 TLR4 抗体)-dependent TNF (显示 TNF 抗体) production in mast cells controlling the inactivation of PP2Ac and activation of PKCalpha (显示 PKCa 抗体)/beta necessary for the secretion of TNF (显示 TNF 抗体) by VAMP3 (显示 VAMP3 抗体)(+) carriers
endogenous siRNA (PTEN-sh-3p21) cleaved from PTEN-sh within PTEN mRNA 3'UTR modulates PPP2CA and PTEN at the post-transcriptional level in liver cells
PP2A (显示 PPP2R2B 抗体) activation both limited and prevented inflammation and tissue injury in two direct injury models of Acute respiratory distress syndrome.
PP2A (显示 PPP2R2B 抗体) regulates kinetochore-microtubule attachment during meiosis I in oocyte.
these results suggest that inhibiting PP2Ac nitration using a mimic peptide is a potential preventive strategy for Endothelial-to-mesenchymal transition in renal fibrosis
Data suggest a critical role for the I2PP2A protein (SET)-protein phosphatase-2A (PP2A) signaling axis in Pten phosphohydrolase
that loss of glucocerebrosidase function may contribute to SNCA accumulation through inhibition of autophagy via PPP2A inactivation
Data indicate that protein phosphatase PP2A is required for the function of T(reg (显示 KCNH2 抗体)) cells and the prevention of autoimmunity.
This work has significantly advanced our understanding of the RACK1 (显示 GNB2L1 抗体)/PP2A (显示 PPP2R4 抗体) complex and suggests a pro-carcinogenic role for the RACK1 (显示 GNB2L1 抗体)/PP2A (显示 PPP2R4 抗体) interaction. This work suggests that approaches to target the RACK1 (显示 GNB2L1 抗体)/PP2A (显示 PPP2R4 抗体) complex are a viable option to regulate PP2A (显示 PPP2R4 抗体) activity and identifies a novel potential therapeutic target in the treatment of breast cancer.
Moreover, PP2Acalpha2-overexpressed cells demonstrated increased expression of IGBP1 (显示 IGBP1 抗体), activated mTORC1 signaling to reduce basal autophagy and increased anchorage-independent growth. Our study provides new insights into the complex mechanisms of PP2A (显示 PPP2R4 抗体) regulation.
protein phosphatase 2A (PP2A (显示 PPP2R4 抗体))-mediated Raf (显示 RAF1 抗体)-MEK (显示 MAP2K1 抗体)-ERK (显示 EPHB2 抗体) signaling was involved in glutaminolysis in endothelial cells.
Studies indicate that protein phosphatase methylesterase-1 (PME-1 (显示 PPME1 抗体)) negatively regulates protein phosphatase 2A (PP2A (显示 PPP2R4 抗体)) activity by highly complex mechanisms.
Binding of PP2A (显示 PPP2R4 抗体) and Akt (显示 AKT1 抗体) increased in response to cAMP or phosphatidic acid (PA), suggesting that their binding is directly responsible for the inactivation of Akt (显示 AKT1 抗体) during decidualization.
Knockdown of Alpha4 preferentially impacts the expression of PP4c (显示 PPP4C 抗体) and PP6c (显示 PPP6C 抗体) compared to expression levels of PP2Ac.
these data support a role for the novel PP2Ac-CIN85 (显示 SH3KBP1 抗体) complex in supporting integrin-dependent platelet function by dampening the phosphatase activity.
PP2Ac upregulation has a poor prognostic impact on the overall survival of hepatocellular carcinoma (HCC (显示 FAM126A 抗体)) patients and contributes to the aggressiveness of HCC (显示 FAM126A 抗体). PP2Ac may represent a potential therapeutic target for HCC (显示 FAM126A 抗体).
Data show that downregulating proto-oncogene (显示 RAB1A 抗体) protein Akt (p-Akt (显示 AKT1 抗体)) by inhibiting PP2A (显示 PPP2R4 抗体) inhibitor SET-mediated protein phosphatase 2A (PP2A (显示 PPP2R4 抗体)) inactivation determined the pro-apoptotic effects of EMQA and paclitaxel combination treatment.
Data suggest a critical role for the I2PP2A protein (SET)-protein phosphatase-2A (PP2A) signaling axis in Pten protein (Pten) deficient castration resistant prostate cancer (CRPC) progression.
changes in PP2A (显示 PPP2R2B 抗体) activity due to methylation and tyrosine phosphorylation occur in sperm; these changes may play an important role in the regulation of sperm function
The findings demonstrate an endothelial VEGF (显示 VEGFA 抗体) resistance mechanism conferred by palmitic acid, which comprises ceramide-induced, PP2A (显示 PPP2R2B 抗体)-mediated dephosphorylation of critical activation sites on enzymes central to vascular homeostasis and angiogenesis.
PP2A (显示 PPP2R2B 抗体) and AIP1 (显示 PDCD6IP 抗体) cooperatively induce activation of ASK1 (显示 MAP3K5 抗体)-JNK (显示 MAPK8 抗体) signaling and vascular endothelial cell apoptosis.
Hsp27 (显示 HSPB1 抗体) is dephosphorylated by PP2A (显示 PPP2R2B 抗体) in dorsal ruffles, in non-caveolar lipid raft microdomains.
This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes an alpha isoform of the catalytic subunit.
protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform
, serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
, protein phosphatase 2a, catalytic subunit, alpha
, protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform
, protein phosphatase 2, catalytic subunit, beta isoform
, protein phosphatase 2, catalytic subunit, alpha isozyme
, serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform-like
, protein phosphatase 2a, catalytic subunit, alpha isoform
, protein phosphatase 2A catalytic subunit, alpha isoform
, replication protein C
, serine/threonine protein phosphatase 2A, catalytic subunit, alpha isoform
, protein phosphatase 2, catalytic subunit, alpha isoform
, protein phosphatase-2A-alpha
, type 2A protein phosphatase catalytic subunit
, protein phosphatase 2A alpha subunit
, phosphatase 2A catalytic subunit