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Human Cyclin D1 Protein expressed in Wheat germ - ABIN1348445
Dannenmann, Hermanns, Bransi, Matter, von Boehmer, Stevanovic, Schraml, Moch, Knuth, van den Broek: Spontaneous peripheral T-cell responses toward the tumor-associated antigen cyclin D1 in patients with clear cell renal cell carcinoma. in Cancer immunology research 2014
PD-L1 (显示 CD274 蛋白) protein abundance is regulated by cyclin D-CDK4 (显示 CDK4 蛋白) and the cullin 3 (显示 CUL3 蛋白)-SPOP (显示 SPOP 蛋白) E3 ligase via proteasome-mediated degradation
We conclude that EMSY (显示 C11orf30 蛋白) and CCND1 work in collaboration and contribute to the pathogenesis of lung cancer.
Transfection of cells with ClC-3 (显示 CLCN3 蛋白) siRNA decreased the expression of cyclin D1, cyclin dependent kinase 4 (显示 CDK4 蛋白) and 6, and increased the expression of cyclin dependent kinase (显示 CDK1 蛋白) inhibitors (CDKIs), p21 (显示 CDKN1A 蛋白) and p27 (显示 PAK2 蛋白). Pretreatments of cells with p21 (显示 CDKN1A 蛋白) and p27 (显示 PAK2 蛋白) siRNAs depleted the inhibitory effects of ClC-3 (显示 CLCN3 蛋白) siRNA on the expression of CDK4 (显示 CDK4 蛋白) and CDK6 (显示 CDK6 蛋白), but not on that of cyclin D1
HPV infection was significantly associated with amplification of both EGFR (显示 EGFR 蛋白) (76.5%) and cyclin D1 (73.0%).
our data demonstrated for the first time that inhibition of RAD51 (显示 RAD51 蛋白) suppressed the cervical cancer cell proliferation and the growth of cervical cancer xenografts by attenuating cell cycle transition, which could be a functional link between RAD51 (显示 RAD51 蛋白) and cyclin D1 and p21 (显示 CDKN1A 蛋白)
REVIEW: addresses the implication of SOX11 (显示 SOX11 蛋白) overexpression and frequent genetic lesions, cooperating with cyclin D1 underlying the pathogenesis of mantle cell lymphoma
A significant association between CCND1 c.870G>A polymorphism and breast cancer risk.
The study demonstrated that UCA1 is a critical regulator involved in gastric cancer cells proliferation and cell cycle progression by promoting cyclin D1 expression.
These findings uncover a new mechanism that is critical for the regulation of CCND1 protein levels, and is directly relevant to primary ibrutinib resistance in MCL (显示 FH 蛋白).
Sphk1 (显示 SPHK1 蛋白) induced NF-kappaB (显示 NFKB1 蛋白)-p65 (显示 GORASP1 蛋白) activation, increased expression of cyclin D1, shortened the cell division cycle, and thus promoted proliferation of breast epithelial cells.
beta-catenin (显示 CTNNB1 蛋白) and p65 (显示 NFkBP65 蛋白) are activated in separate cellular compartments during liver regeneration, with p65 (显示 NFkBP65 蛋白) activity in nonparenchymal compartment contributing to the activation of hepatocyte beta-catenin (显示 CTNNB1 蛋白), cyclin D1 expression, and subsequent proliferation
Ablation of periostin (显示 POSTN 蛋白) suppresses post-infarction myocardial regeneration by inhibiting the PI3K/GSK3beta/cyclin D1 signalling pathway, indicating that periostin (显示 POSTN 蛋白) is essential for myocardial regeneration.
Cyclin D1 is indispensable for normal hematopoiesis; in its absence, cyclins D2 and D3 are also not expressed, preventing hematopoietic cell division and differentiation at its earliest stage. The results demonstrate that not all functions of individual D cyclins are redundant, and highlight a master role of cyclin D1 in hematopoiesis.
NMB or NMBR silencing inhibited M-CSF (显示 CSF1R 蛋白)/c-Fms (显示 CSF1R 蛋白)-mediated downstream signaling pathways like activation of ERK (显示 EPHB2 蛋白) and Akt (显示 AKT1 蛋白) and induction of D-type cyclins, cyclin D1 and D2.
Histone H2A T120 phosphorylation promotes oncogenic transformation via upregulation of cyclin D1.
our results are consistent with an epithelial proliferative growth mechanism linking CTNNB1 (显示 CTNNB1 蛋白)-driven Ccnd1 transcription and estrogen-mediated CCND1 protein stabilization.
identify Pax5 (显示 PAX5 蛋白) and cyclin D1 as Zfp521 target genes, and suggest that excessive B-cell proliferation observed in mice with retroviral insertions near the Zfp521 gene is due to an up-regulation of cyclin D1 in B-cells.
Data show that expression of the Oct-4 (显示 POU5F1 蛋白), Sox2 (显示 SOX2 蛋白), Klf4 (显示 KLF4 蛋白), and c-Myc (显示 MYC 蛋白) (OSKM) reprogramming factors induces Cyclin D1 expression, and the increased Cyclin D1 expression during reprogramming promotes continuing embryonic fibroblasts (MEFs) proliferation.
study shows that PLCgamma1 (显示 PLCG1 蛋白) controls osteoclast numbers via a CSF-1 (显示 CSF1 蛋白)-dependent DAG/beta-catenin (显示 CTNNB1 蛋白)/cyclinD1 pathway.
Regarding extratelomeric activities, our results showed a decrease of 64, 38 and 25% in the transcription of c-Myc (显示 MYC 蛋白), Cyc (显示 CYCS 蛋白)-D1 and TERT (显示 TERT 蛋白), respectively (p<0.05) after AZT treatment. Furthermore, we found an effect on cell migration, reaching an inhibition of 48% (p<0.05) and a significant passage-dependent increase on cell doubling time during treatment.
while cyclin B1 RNA granules were disassembled in a manner dependent on actin filament depolymerization, certain fractions of mos RNA granules were disassembled independently of actin filaments. These results suggest that cytoplasmic regulation of translationally repressed mRNAs by formation of different RNA granules is a key mechanism for translational control of
show that the knockdown of smc1a (显示 SMC1A 蛋白) in zebrafish impairs neural development, increases apoptosis, and specifically down-regulates Ccnd1 levels
Reduction of cyclin D1 expression compromises zebrafish eye and head development.
Role in cell cycle control is mediated by meis1 (显示 MEIS1 蛋白) regulating cyclin D1 and c-myc (显示 MYC 蛋白) transcription in the embryonic eye.
Results suggest that the TCF (显示 HNF4A 蛋白)/LEF signaling pathway participates in the regulation of cyclin D1 induction during the generation of the dorsal nervous system in early frog embryogenesis.
CCND1 mRNA expression is increased by FGF9 in bovine theca cells and granulosa cells.
cyclin D1, CDK2 (显示 CDK2 蛋白) and CDK4 (显示 CDK4 蛋白) are expressed in both caruncular and intercaruncular cells derived from both nonpregnant, and artificially inseminated cows on days 30 and 60 of gestation
17beta-estradiol (E2) induces cell proliferation of bovine arterial endothelial cells through upregulation of cyclin D1 via non-genomic activation of the extracellular signal-regulated microtubule-associated Protein 2 kinase (ERK1 (显示 MAPK3 蛋白) kinase) pathway.
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis.
B-cell CLL/lymphoma 1
, B-cell lymphoma 1 protein
, BCL-1 oncogene
, G1/S-specific cyclin-D1
, PRAD1 oncogene
, G1/S-specific cyclin-D1 b
, cyclin D1 b
, parathyroid adenomatosis 1
, G1/S-specific cyclin-D1 a
, cyclin D1 a (PRAD1: parathyroid adenomatosis 1)
, cyclin D1 (PRAD1: parathyroid adenomatosis 1)
, cyclin D1