(Peptidyl Prolyl Cis/Trans Isomerase NIMA Interacting 4 Protein (PIN4))
This gene encodes a member of the parvulin subfamily of the peptidyl-prolyl cis/trans isomerase protein family. The encoded protein catalyzes the isomerization of peptidylprolyl bonds, and may play a role in the cell cycle, chromatin remodeling, and/or ribosome biogenesis. The encoded protein may play an additional role in the mitochondria. [provided by RefSeq, Dec 2009].
Kessler, Papatheodorou, Stratmann, Dian, Hartmann-Fatu, Rassow, Bayer, Mueller: "The DNA binding parvulin Par17 is targeted to the mitochondrial matrix by a recently evolved prepeptide uniquely present in Hominidae." in: BMC biology, Vol. 5, pp. 37, (2007) (PubMed).