PMS2 Postmeiotic Segregation Increased 2 (S. Cerevisiae) (PMS2) (Middle Region) Peptide
PMS2
适用: 人
宿主: 合成
BP, WB
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- 抗原 See all PMS2 products
- PMS2 (PMS2 Postmeiotic Segregation Increased 2 (S. Cerevisiae) (PMS2))
- 蛋白结构域
- Middle Region
- 宿主
- 人
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资源
- 合成
- 应用范围
- Blocking Peptide (BP), Western Blotting (WB)
- 产品特性
- This is a synthetic peptide designed for use in combination with anti-PMS2 antibody (Catalog #: ARP56117_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- 纯化方法
- Purified
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- 应用备注
- Each Investigator should determine their own optimal working dilution for specific applications.
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- 浓度
- 1 mg/mL
- 缓冲液
- Final peptide concentration is 1 mg/mL in PBS.
- 注意事项
- Avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- 抗原
- PMS2 (PMS2 Postmeiotic Segregation Increased 2 (S. Cerevisiae) (PMS2))
- 背景
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PMS2 is involved in DNA mismatch repair. It forms a heterodimer with MLH1 and this complex interacts with other complexes bound to mismatched bases. Mutations in this gene are associated with hereditary nonpolyposis colorectal cancer, Turcot syndrome, and are a cause of supratentorial primitive neuroectodermal tumors.This gene is one of the PMS2 gene family members found in clusters on chromosome 7. The product of this gene is involved in DNA mismatch repair. It forms a heterodimer with MLH1 and this complex interacts with other complexes bound to mismatched bases. Mutations in this gene are associated with hereditary nonpolyposis colorectal cancer, Turcot syndrome, and are a cause of supratentorial primitive neuroectodermal tumors. Alternatively spliced transcript variants have been observed for this gene.
Alias Symbols: HNPCC4, PMS2CL, PMSL2
Protein Interaction Partner: EXO1,MLH1,EXO1,MLH1,AIFM1,ATAD3A,BRCA2,BRIP1,COPB1,COPG,COPG2,CYLD,DDB1,EXO1,KPNA2,KPNB1,MCM3,MLH1,MMS19,MSH2,MSH3,MSH6,MTMR15,NSUN2,PCNA,PIK3C2A,PPP2CA,PRKDC,PSD2,PSD3,PSMC1,PSMC2,PSMC3,PSMC6,PSMD5,RFC2,RUVBL1,RUVBL2,SMARCA4,UBC,UBR5,XPO1
Protein Size: 862 - 分子量
- 96 kDa
- 基因ID
- 5395
- NCBI登录号
- NM_000535, NP_000526
- UniProt
- P54278
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