Poly(rC) Binding Protein 2 (PCBP2) Peptide
PCBP2
适用: 人
宿主: 合成
BP, WB, IHC
产品编号 ABIN981429
发货至:
中国
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Contact Info
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中国
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北京 101111
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Quick Overview for Poly(rC) Binding Protein 2 (PCBP2) Peptide (ABIN981429)
抗原
PCBP2
(Poly(rC) Binding Protein 2 (PCBP2))
宿主
人
资源
合成
应用范围
Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
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产品特性
- This is a synthetic peptide designed for use in combination with anti-PCBP2 antibody (Catalog #: ARP40568_T100). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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纯化方法
- Purified
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应用备注
- Each Investigator should determine their own optimal working dilution for specific applications.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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浓度
- 1 mg/mL
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缓冲液
- Final peptide concentration is 1 mg/mL in PBS.
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注意事项
- Avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- PCBP2 (Poly(rC) Binding Protein 2 (PCBP2))
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背景
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PCBP2 appears to be multifunctional. It along with PCBP-1 and hnRNPK corresponds to the major cellular poly(rC)-binding proteins. This protein together with PCBP-1 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. This gene and PCBP-1 has paralogues PCBP3 and PCBP4 which is thought to arose as a result of duplication events of entire genes.The protein encoded by this gene appears to be multifunctional. It along with PCBP-1 and hnRNPK corresponds to the major cellular poly(rC)-binding proteins. It contains three K-homologous (KH) domains which may be involved in RNA binding. This encoded protein together with PCBP-1 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. This multiexon structural mRNA is thought to be retrotransposed to generate PCBP-1 intronless gene which has similar functions. This gene and PCBP-1 has paralogues PCBP3 and PCBP4 which is thought to arose as a result of duplication events of entire genes. It also has two processed pseudogenes PCBP2P1 and PCBP2P2. There are presently two alternatively spliced transcript variants described for this gene.
Alias Symbols: HNRPE2, hnRNP-E2
Protein Interaction Partner: CNBP,CSDA,FLNA,HNRNPD,HNRNPK,HNRNPL,PABPC1,PCBP1,PCBP2,PRPF40A,PTBP1,QKI,SRSF3,SRSF7,YBX1,CDK9,HNRNPK,HNRNPL,MEPCE,PCBP2,POLR3H,PTBP1,RUVBL1,RUVBL2
Protein Size: 366 -
分子量
- 40 kDa
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基因ID
- 5094
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NCBI登录号
- NM_005016, NP_005007
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UniProt
- Q6IPF4
抗原
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