Nucleoporin 98kDa (NUP98) Peptide
NUP98
适用: 人
宿主: 合成
BP, WB
-
- 抗原 See all NUP98 products
- NUP98 (Nucleoporin 98kDa (NUP98))
- 宿主
- 人
-
资源
- 合成
- 应用范围
- Blocking Peptide (BP), Western Blotting (WB)
- 产品特性
- This is a synthetic peptide designed for use in combination with anti-NUP98 antibody (Catalog #: ARP53631_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- 纯化方法
- Purified
-
-
- 应用备注
- Each Investigator should determine their own optimal working dilution for specific applications.
- 限制
- 仅限研究用
-
- 状态
- Lyophilized
- 溶解方式
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- 浓度
- 1 mg/mL
- 缓冲液
- Final peptide concentration is 1 mg/mL in PBS.
- 注意事项
- Avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
-
- 抗原
- NUP98 (Nucleoporin 98kDa (NUP98))
- 别名
- CG10198 Peptide, CG10201 Peptide, Dmel\\CG10198 Peptide, Nup 96 Peptide, Nup 98 Peptide, Nup-98 Peptide, Nup96 Peptide, Nup98 Peptide, Nup98-Nup96 Peptide, Nup98/96 Peptide, l(3)95BCd Peptide, nup145 Peptide, nup98-96 Peptide, GB12688 Peptide, NUP98 Peptide, 4732457F17 Peptide, AI849286 Peptide, im:7151238 Peptide, zgc:113968 Peptide, zgc:63593 Peptide, ADIR2 Peptide, NUP196 Peptide, NUP96 Peptide, Nucleoporin 98-96kD Peptide, nuclear pore complex protein Nup98-Nup96 Peptide, nucleoporin 98 Peptide, nucleoporin 98kDa Peptide, nucleoporin 98 L homeolog Peptide, Nup98-96 Peptide, LOC408335 Peptide, NUP98 Peptide, LOC587580 Peptide, Nup98 Peptide, nup98 Peptide, nup98.L Peptide
- 背景
-
The nuclear pore complex (NPC) is comprised of approximately 50 unique proteins collectively known as nucleoporins. The 98 kD nucleoporin is localized to the nucleoplasmic side of the NPC. Rat studies show that the 98 kD nucleoporin functions as one of several docking site nucleoporins of transport substrates. The human gene has been shown to fuse to several genes following chromsome translocatons in acute myelogenous leukemia (AML) and T-cell acute lymphocytic leukemia (T-ALL). This gene is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Signal-mediated nuclear import and export proceed through the nuclear pore complex (NPC), which is comprised of approximately 50 unique proteins collectively known as nucleoporins. The 98 kD nucleoporin is generated through a biogenesis pathway that involves synthesis and proteolytic cleavage of a 186 kD precursor protein. This cleavage results in the 98 kD nucleoporin as well as a 96 kD nucleoporin, both of which are localized to the nucleoplasmic side of the NPC. Rat studies show that the 98 kD nucleoporin functions as one of several docking site nucleoporins of transport substrates. The human gene has been shown to fuse to several genes following chromsome translocatons in acute myelogenous leukemia (AML) and T-cell acute lymphocytic leukemia (T-ALL). This gene is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Alternative splicing of this gene results in several transcript variants, however, not all variants have been fully described.
Alias Symbols: ADIR2, NUP196, NUP96
Protein Interaction Partner: CREBBP,EP300,IPO5,KPNB1,NUP133,NUP62,NUP88,NUP98,NXF1,RAE1,RCC1,SEC13,TNPO1,TPR,CREBBP,CRM1,EP300,KAP104,KPNB1,MOBKL1B,NFX1,NPM1,NUP133,NUP88,NXF1,PARP11,QRICH2,RAE1,Rae1,TNPO1,TNPO2,TPR,USP7
Protein Size: 937 - 分子量
- 98 kDa
- 基因ID
- 4928
- NCBI登录号
- NM_005387, NP_005378
- UniProt
- A8KA17
-
You are here:
