Lymphocyte-Specific Protein tyrosine Kinase (LCK) Peptide
LCK
适用: 人
宿主: 合成
BP, WB
产品编号 ABIN979230
发货至:
中国
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Contact Info
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中国
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北京 101111
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Quick Overview for Lymphocyte-Specific Protein tyrosine Kinase (LCK) Peptide (ABIN979230)
抗原
LCK
(Lymphocyte-Specific Protein tyrosine Kinase (LCK))
宿主
人
资源
合成
应用范围
Blocking Peptide (BP), Western Blotting (WB)
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产品特性
- This is a synthetic peptide designed for use in combination with anti-LCK antibody (Catalog #: ARP54525_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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纯化方法
- Purified
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应用备注
- Each Investigator should determine their own optimal working dilution for specific applications.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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浓度
- 1 mg/mL
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缓冲液
- Final peptide concentration is 1 mg/mL in PBS.
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注意事项
- Avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- LCK (Lymphocyte-Specific Protein tyrosine Kinase (LCK))
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背景
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LCK is a member of the Src family of protein tyrosine kinases (PTKs). It is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. LCK localizes to the plasma membrane and pericentrosomal vesicles, and binds to cell surface receptors, including CD4 and CD8, and other signaling molecules.This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to the plasma membrane and pericentrosomal vesicles, and binds to cell surface receptors, including CD4 and CD8, and other signaling molecules. Multiple alternatively spliced variants, encoding the same protein, have been described.
Alias Symbols: YT16, p56lck, pp58lck, LSK
Protein Interaction Partner: CD8B,DNM2,HCVgp1,KHDRBS1,NFKBIA,ACP1,ADAM15,AXL,BCAR1,CBL,CCR5,CD2,CD247,CD28,CD38,CD3E,CD4,CD44,CD48,CD5,CD55,CD79A,CD79B,CD8A,CDC25C,CDC42,CSF2RB,CSF3R,CSK,CTLA4,CTNND2,DAPP1,DEF6,DLG1,DOK1,DOK2,DOK3,ESR1,EZR,FAS,FASLG,FCGR3A,GAB2,GRAP,HSP90AA1,IFNAR1,IL2RB,ITK,JAK3,KHDRBS1,KIR2DL3,KIT,LAT,LAX1,LCK,LCP2,LIME1,MAPK1,MAPK3,MED28,MS4A1,MUC1,NEDD9,NFKBIA,NOTCH1,NR3C1,PAG1,PAK2,PECAM1,PIK3CA,PIK3R1,PLCG1,PLCG2,PLD2,PRKACA,PRKCA,PRKCD,PRKCQ,PTK2,PTK2B,PTPN11,PTPN22,PTPN6,PTPRC,PTPRF,PTPRH,PXN,RAF1,RASA1,SH2B3,SH2D1A,SH2D2A,SH3BP2,SHC1,SIT1,SKAP1,SQSTM1,STAT1,STAT3,STAT5A,SYK,THY1,TRAT1,TRPV4,TUB,UNC119,VAV1,ZAP70,ADAM10,ADAM15,ARHGAP17,AXL,BCAR1,CBL,CD2,CD4,CD44,CD48,CTLA4,CTNND1,Cd3e,DLG1,FAS,FASLG,KHDRBS1,KIT,MS4A1,NEDD9,NOTCH1,NR2F2,PAG1,PECAM1,PI4KA,PIK3CA,PIK3R1,PRKCQ,PTK2B,PTPN6,PTPRC,PXN,RAF1,RASA1,SH2B3,SIT1,SKAP1,SQSTM1,SYK,THY1,TRAT1,TRPV4,UBE3A,UNC119,ZAP70
Protein Size: 509 -
分子量
- 58 kDa
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基因ID
- 3932
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NCBI登录号
- NM_001042771, NP_001036236
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UniProt
- P06239
抗原
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