Karyopherin (Importin) beta 1 (KPNB1) (N-Term) Peptide
KPNB1
适用: 人
宿主: 合成
BP, WB
产品编号 ABIN979105
发货至:
中国
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Quick Overview for Karyopherin (Importin) beta 1 (KPNB1) (N-Term) Peptide (ABIN979105)
抗原
KPNB1
(Karyopherin (Importin) beta 1 (KPNB1))
宿主
人
资源
合成
应用范围
Blocking Peptide (BP), Western Blotting (WB)
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蛋白结构域
- N-Term
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序列
- EHMKESTLEA IGYICQDIDP EQLQDKSNEI LTAIIQGMRK EEPSNNVKLA
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产品特性
- This is a synthetic peptide designed for use in combination with anti-KPNB1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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纯化方法
- Purified
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应用备注
- Each Investigator should determine their own optimal working dilution for specific applications.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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浓度
- 1 mg/mL
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缓冲液
- Final peptide concentration is 1 mg/mL in PBS.
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注意事项
- Avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- KPNB1 (Karyopherin (Importin) beta 1 (KPNB1))
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背景
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Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. Interactions between importin beta and the FG repeats of nucleoporins are essential in translocation through the pore complex. The protein encoded by this gene is a member of the importin beta family.
Alias Symbols: IMB1, IPO1, IPOB, Impnb, MGC2155, MGC2156, MGC2157, NTF97
Protein Interaction Partner: CD99,RAN,SOX9,rev,tat,CD99,CHD3,CSE1L,CSNK1A1,ELAVL1,FGFR1,H1F0,IGFBP3,IGFBP5,IPO7,IPO8,KPNA2,KPNA3,KPNA6,KPNB1,LYST,NFYA,NUP153,NUP50,NUP62,NUP98,PIAS4,PLCD1,PRKD3,PTHLH,PTMA,PTN,PTPN2,RAN,RANBP2,RPL5,RUNX1T1,SMAD2,SMAD3,SMN2,SMNDC1,SNUPN,SOX9,SREBF2,TER
Protein Size: 876 -
分子量
- 96 kDa
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基因ID
- 3837
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NCBI登录号
- NM_002265, NP_002256
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UniProt
- Q14974
抗原
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