Interleukin 7 Receptor (IL7R) (Middle Region) Peptide
IL7R
适用: 人
宿主: 合成
BP, WB
产品编号 ABIN978517
发货至:
中国
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Contact Info
Our Local Distributor
中国
北京 101111
北京 101111
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Quick Overview for Interleukin 7 Receptor (IL7R) (Middle Region) Peptide (ABIN978517)
抗原
IL7R
(Interleukin 7 Receptor (IL7R))
宿主
人
资源
合成
应用范围
Blocking Peptide (BP), Western Blotting (WB)
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蛋白结构域
- Middle Region
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序列
- ESFLDCQIHR VDDIQARDEV EGFLQDTFPQ QLEESEKQRL GGDVQSPNCP
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产品特性
- This is a synthetic peptide designed for use in combination with anti-IL7R Antibody(ARP59084_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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纯化方法
- Purified
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应用备注
- Each Investigator should determine their own optimal working dilution for specific applications.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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浓度
- 1 mg/mL
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缓冲液
- Final peptide concentration is 1 mg/mL in PBS.
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注意事项
- Avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- IL7R (Interleukin 7 Receptor (IL7R))
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背景
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The protein encoded by this gene is a receptor for interleukine 7 (IL7). The function of this receptor requires the interleukin 2 receptor, gamma chain (IL2RG), which is a common gamma chain shared by the receptors of various cytokines, including interleukine 2, 4, 7, 9, and 15. This protein has been shown to play a critical role in the V(D)J recombination during lymphocyte development. This protein is also found to control the accessibility of the TCR gamma locus by STAT5 and histone acetylation. Knockout studies in mice suggested that blocking apoptosis is an essential function of this protein during differentiation and activation of T lymphocytes. The functional defects in this protein may be associated with the pathogenesis of the severe combined immunodeficiency (SCID).
Alias Symbols: CD127, CDW127, IL-7R-alpha, IL7RA, ILRA
Protein Interaction Partner: IL7,CRLF2,FYN,IL2RG,IL7,JAK1,JAK3,LYN,PIK3R1,PTK2B,STAT3,STAT5A,STAT5B,TSLP,FYN,PTK2B
Protein Size: 459 -
分子量
- 49 kDa
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基因ID
- 3575
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NCBI登录号
- NM_002185, NP_002176
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UniProt
- P16871
抗原
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