Deoxynucleotidyltransferase, terminal (DNTT) (Middle Region) Peptide
DNTT
适用: 人
宿主: 合成
BP, WB
产品编号 ABIN975940
发货至:
中国
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Contact Info
Our Local Distributor
中国
北京 101111
北京 101111
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Beijing Economic Technological Development Area
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Quick Overview for Deoxynucleotidyltransferase, terminal (DNTT) (Middle Region) Peptide (ABIN975940)
抗原
TdT (DNTT)
(Deoxynucleotidyltransferase, terminal (DNTT))
宿主
人
资源
合成
应用范围
Blocking Peptide (BP), Western Blotting (WB)
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蛋白结构域
- Middle Region
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产品特性
- This is a synthetic peptide designed for use in combination with anti-DNTT antibody (Catalog #: ARP52032_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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纯化方法
- Purified
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应用备注
- Each Investigator should determine their own optimal working dilution for specific applications.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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浓度
- 1 mg/mL
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缓冲液
- Final peptide concentration is 1 mg/mL in PBS.
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注意事项
- Avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- TdT (DNTT) (Deoxynucleotidyltransferase, terminal (DNTT))
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背景
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DNTT is the template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. One of the in vivo functions of this enzyme is the addition of nucleotides at the junction (N region) of rearranged Ig heavy chain and T-cell receptor gene segments during the maturation of B- and T-cells.This gene is a member of the DNA polymerase type-X family and encodes a template-independent DNA polymerase that catalyzes the addition of deoxynucleotides to the 3'-hydroxyl terminus of oligonucleotide primers. In vivo, the encoded protein is expressed in a restricted population of normal and malignant pre-B and pre-T lymphocytes during early differentiation, where it generates antigen receptor diversity by synthesizing non-germ line elements (N-regions) at the junctions of rearranged Ig heavy chain and T cell receptor gene segments. Alternatively spliced transcript variants encoding different isoforms of this gene have been described.
Alias Symbols: TDT
Protein Interaction Partner: DNTTIP1,DNTTIP2,PCNA,PRPF19,XRCC6,ABTB2,CUL3,DNTTIP2,PCNA,PRPF19,UBC,XRCC6
Protein Size: 509 -
分子量
- 58 kDa
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基因ID
- 1791
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NCBI登录号
- NM_004088, NP_004079
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UniProt
- P04053
抗原
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