V-Akt Murine Thymoma Viral Oncogene Homolog 1 (AKT1) Peptide
AKT1
适用: 人
宿主: 合成
BP, WB
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- 抗原 See all AKT1 products
- AKT1 (V-Akt Murine Thymoma Viral Oncogene Homolog 1 (AKT1))
- 宿主
- 人
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资源
- 合成
- 应用范围
- Blocking Peptide (BP), Western Blotting (WB)
- 产品特性
- This is a synthetic peptide designed for use in combination with anti-AKT1 antibody (Catalog #: AVARP06008_T100). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- 纯化方法
- Purified
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- 应用备注
- Each Investigator should determine their own optimal working dilution for specific applications.
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- 浓度
- 1 mg/mL
- 缓冲液
- Final peptide concentration is 1 mg/mL in PBS.
- 注意事项
- Avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- 抗原
- AKT1 (V-Akt Murine Thymoma Viral Oncogene Homolog 1 (AKT1))
- 背景
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AKT1 is a general protein kinase capable of phosphorylating several known proteins.The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Multiple alternatively spliced transcript variants have been found for this gene.
Alias Symbols: AKT, PKB, RAC, PRKBA, PKB-ALPHA, RAC-ALPHA
Protein Interaction Partner: APPL1,AR,FOXO4,GSK3B,HTT,IMPDH2,MDM2,NCF1C,PDK1,PDPK1,PEA15,PIAS2,PRKDC,TCL1A,TCL1B,TSC2,YWHAZ,YWHAZ,CSNK2A1,METTL1,PHLPP1,YBX1,AHNAK,AKT1,AKT1S1,AKT2,AKTIP,APLP2,APPL1,AR,ATXN1,BAD,BCL10,BCL2L11,BRAF,BRCA1,CAMKK1,CASP3,CASP9,CCDC88A,CDKN1A,CDKN1B,CHEK1,CHUK,CREB1,DLC1,EIF4EBP1,EP300,ESR1,ESR2,EZH2,FANCA,FOXO1,FOXO3,FOXO4,GAB2,GATA1,GATA2,GRB10,GSK3A,GSK3B,HIST2H2BE,HMOX1,HSP90AA1,HSP90AB1,HTT,IKBKB,ILK,IMPDH2,IRAK1,IRS1,ITGB3,KRT10,MAP2K4,MAP3K11,MAP3K5,MAP3K8,MAPK8IP1,MAPKAPK2,MDM2,MDM4,METTL1,MS4A2,MST1R,MTCP1,MTOR,NCF1,NOS3,NR4A1,PAK1,PDE3B,PDK2,PDPK1,PEA15,PFKFB2,PHB2,PIK3R1,PKN2,PLXNA1,PPARGC1B,PPL,PPM1A,PPP2CA,PRG2,PRKCQ,PRKCZ,PRKDC,PTEN,PTPN1,RAB3D,RAC1,RAF1,RHEBL1,RPS6KB1,S1PR1,SH2B2,SMAD2,SMAD3,SMAD4,SMAD7,SORBS2,SRC,STAT1,TCL1A,TCL1B,TERT,THEM4,TNFSF11,TOPBP1,TRIB3,TSC1,TSC2,UXS1,VEGFA,WNK1,XIAP,YAP1,YBX1,YWHAZ,AKTIP,AR,ARFIP2,ARHGAP29,ARHGAP32,Akt2,BAD,BRAF,BRCA1,CARHSP1,CDKN1B,CHN2,CHUK,FANCA,GAB2,GSK3B,HSP90AA1,HSP90AB1,HSPB1,ILK,ILK,IMPDH2,IRAK1,IRS1,KRT10,KTN1,MAP2K4,MAP3K11,MAP3K8,MAPK14,MAPK8IP1,MAPKAP1,MAPKAPK2,MARK2,MTCP1,MTOR,NF2,NPM1,NR4A1,PAK1,PAK6,PDPK1,PIAS1,PIAS2,PKN2,PLXNA1,PLXNB1,PRKCQ,PRKCZ,RAF1,RICTOR,RPS6KB1,SMAD2,SMAD3,SMAD4,SMAD7,STUB1,TCL1A,TCL1B,TERT,THEM4,TRIB3,TSC1,TSC2,UBC,USP8,YWHAZ
Protein Size: 480 - 分子量
- 56 kDa
- 基因ID
- 207
- NCBI登录号
- NM_005163, NP_005154
- UniProt
- P31749
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