A synthetic peptide for use as a blocking control in assays to test for specificity of ACTN4 antibody, Alternative Names: alpha Actinin 4 control peptide, alpha Actinin 4 antibody Blocking Peptide, Anti-alpha Actinin 4 Blocking Peptide, ACTN4 Blocking Peptide, DKFZp686K23158 Blocking Peptide, FSGS Blocking Peptide, FSGS1 Blocking Peptide
Alpha actinins belong to the spectrin superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. ACTN4 is a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and thought to be involved in metastatic processes. Alpha actinin is an actin-binding protein with multiple roles in different cell types.