A synthetic peptide for use as a blocking control in assays to test for specificity of PSMD12 antibody, Alternative Names: PSMD12 control peptide, PSMD12 antibody Blocking Peptide, Anti-PSMD12 Blocking Peptide, Proteasome macropain 26S subunit non-ATPase 12 Blocking Peptide, Prosome Macropain 26S Subunit Non-Atpase 12 Blocking Peptide, MGC75406 Blocking Peptide, p55 Blocking Peptide, PSMD12, PSMD-12, PSMD 12, PSMD-12 Blocking Peptide, PSMD 12 Blocking Peptide
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits, 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. A pseudogene has been identified on chromosome 3.