A synthetic peptide for use as a blocking control in assays to test for specificity of METAP2 antibody, Alternative Names: METAP2 control peptide, METAP2 antibody Blocking Peptide, Anti-METAP2 Blocking Peptide, Methionyl Aminopeptidase 2 Blocking Peptide, MAP2 Blocking Peptide, MNPEP Blocking Peptide, p67 Blocking Peptide, p67eIF2 Blocking Peptide, METAP2, METAP-2, METAP 2, METAP-2 Blocking Peptide, METAP 2 Blocking Peptide
纯化方法
The antibody is affinity-purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen.
METAP2 is a member of the methionyl aminopeptidase family and encodes a protein that binds 2 cobalt or manganese ions. This protein functions both by protecting the alpha subunit of eukaryotic initiation factor 2 from inhibitory phosphorylation and by removing the amino-terminal methionine residue from nascent protein. Increased expression of this gene is associated with various forms of cancer and the anti-cancer drugs fumagillin and ovalicin inhibit the protein by irreversibly binding to its active site.