MHC Class I Polypeptide-Related Sequence A (MICA) (Middle Region) Peptide
Our Local Distributor
北京 101111
Quick Overview for MHC Class I Polypeptide-Related Sequence A (MICA) (Middle Region) Peptide (ABIN8105364)
抗原
宿主
资源
应用范围
-
-
蛋白结构域
- Middle Region
-
原理
- MICA Peptide - middle region
-
序列
- QKEGLHSLQE IRVCEIHEDN STRSSQHFYY DGELFLSQNL ETKEWTMPQS
-
-
-
-
应用备注
- Optimal working dilution should be determined by the investigator.
-
说明
-
This is a synthetic peptide designed for use in combination with anti-MICA Antibody (ARP77876_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
-
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
溶解方式
- Add 100 µL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
-
缓冲液
- Lyophilized powder
-
储存条件
- -20 °C
-
储存方法
- For longer periods of storage, store at -20 °C. Avoid repeat freeze-thaw cycles.
-
-
- MICA (MHC Class I Polypeptide-Related Sequence A (MICA))
-
背景
-
Background Information: This gene encodes the highly polymorphic major histocompatability complex class I chain-related protein A. The protein product is expressed on the cell surface, although unlike canonical class I molecules it does not seem to associate with beta-2-microglobulin. It is a ligand for the NKG2-D type II integral membrane protein receptor. The protein functions as a stress-induced antigen that is broadly recognized by intestinal epithelial gamma delta T cells. Variations in this gene have been associated with susceptibility to psoriasis 1 and psoriatic arthritis, and the shedding of MICA-related antibodies and ligands is involved in the progression from monoclonal gammopathy of undetermined significance to multiple myeloma. Alternative splicing of this gene results in multiple transcript variants.
Alternative Symbols: MIC-A, PERB11.1
-
分子量
- 42 kDa
-
基因ID
- 100507436
-
NCBI登录号
- NP_000238
-
UniProt
- Q29983
抗原
-
