Maternal Embryonic Leucine Zipper Kinase (MELK) (Middle Region) Peptide
MELK
适用: 人
宿主: 合成
BP, WB
产品编号 ABIN5511345
发货至:
中国
Contact our Customer Service for availability and price in your country.
Contact Info
Our Local Distributor
中国
北京 101111
北京 101111
No. 88 KeChuang 6th Street
Beijing Economic Technological Development Area
Room 801-803
Quick Overview for Maternal Embryonic Leucine Zipper Kinase (MELK) (Middle Region) Peptide (ABIN5511345)
抗原
MELK
(Maternal Embryonic Leucine Zipper Kinase (MELK))
宿主
人
资源
合成
应用范围
Blocking Peptide (BP), Western Blotting (WB)
-
-
蛋白结构域
- Middle Region
-
序列
- MEETPKRKGA KVFGSLERGL DKVITVLTRS KRKGSARDGP RRLKLHYNVT
-
产品特性
- This is a synthetic peptide designed for use in combination with anti-MELK Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
-
-
Maternal Embryonic Leucine Zipper Kinase (MELK) peptide
MELK 适用: 人, 小鼠, Cow, 犬 宿主: 合成 BP, Imm
-
-
应用备注
- Optimal working dilution should be determined by the investigator.
-
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
溶解方式
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
-
储存条件
- -20 °C
-
储存方法
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
-
-
- MELK (Maternal Embryonic Leucine Zipper Kinase (MELK))
-
背景
-
MELK is a serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation. Has a broad substrate specificity, phosphorylates BCL2L14, CDC25B, MAP3K5/ASK1 and ZNF622. Acts as an activator of apoptosis by phosphorylating and activating MAP3K5/ASK1. It acts as a regulator of cell cycle, notably by mediating phosphorylation of CDC25B, promoting localization of CDC25B to the centrosome and the spindle poles during mitosis. And it plays a key role in cell proliferation and carcinogenesis. Required for proliferation of embryonic and postnatal multipotent neural progenitors. Phosphorylates and inhibits BCL2L14, possibly leading to affect mammary carcinogenesis by mediating inhibition of the pro-apoptotic function of BCL2L14. Also involved in the inhibition of spliceosome assembly during mitosis by phosphorylating ZNF622, thereby contributing to its redirection to the nucleus. It may also play a role in primitive hematopoiesis.
Alias Symbols: MELK,KIAA0175,
Protein Size: 457 -
基因ID
- 9833
抗原
-
You are here:
