Tyrosyl-DNA Phosphodiesterase 1 (TDP1) (C-Term) Peptide
TDP1
适用: 小鼠, 人
宿主: 合成
BP, WB
产品编号 ABIN2185631
发货至:
中国
Contact our Customer Service for availability and price in your country.
Contact Info
Our Local Distributor
中国
北京 101111
北京 101111
No. 88 KeChuang 6th Street
Beijing Economic Technological Development Area
Room 801-803
Quick Overview for Tyrosyl-DNA Phosphodiesterase 1 (TDP1) (C-Term) Peptide (ABIN2185631)
抗原
TDP1
(Tyrosyl-DNA Phosphodiesterase 1 (TDP1))
宿主
小鼠, 人
资源
合成
应用范围
Blocking Peptide (BP), Western Blotting (WB)
-
-
蛋白结构域
- C-Term
-
序列
- GRPPGKSAVP LHLIYPSVEN VRTSLEGYPA GGSLPYSIQT AEKQRWLHSY
-
产品特性
- This is a synthetic peptide designed for use in combination with anti-Tdp1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
-
纯化方法
- Purified
-
-
-
-
应用备注
- Optimal working dilution should be determined by the investigator.
-
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
溶解方式
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
-
浓度
- 1 mg/mL
-
缓冲液
- Final peptide concentration is 1 mg/mL in PBS.
-
注意事项
- Avoid repeat freeze-thaw cycles.
-
储存条件
- -20 °C
-
储存方法
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
-
-
- TDP1 (Tyrosyl-DNA Phosphodiesterase 1 (TDP1))
-
背景
-
Tdp1 is a DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate. It catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase I active site tyrosine residue and Hydrolyzes 3'-phosphoglycolates on protruding 3' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. Tdp1 acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. It Has low h3'exonuclease activity and can remove a single nucleoside from the 3'end of DNA and RNA molecules with 3'hydroxyl groups and has no exonuclease activity towards DNA or RNA with a 3'phosphate.
Protein Size: 609 -
分子量
- 66 kDa
-
UniProt
- Q8BJ37
抗原
-
You are here:
