PEN2 抗体
(Presenilin Enhancer 2 Homolog (PSENEN))
Presenilins, which are components of the gamma-secretase protein complex, are required for intramembranous processing of some type I transmembrane proteins, such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta-amyloid precursor protein generates neurotoxic amyloid beta peptides, the major component of senile plaques associated with Alzheimer's disease. This gene encodes a protein that is required for Notch pathway signaling, and for the activity and accumulation of gamma-secretase. [provided by RefSeq, Jul 2008].
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43 results
PSENEN
适用: 人
WB, IF, IHC, ICC
宿主: 兔
Monoclonal
R08-5F0R08-5F0
unconjugated
Recombinant Antibody
PSENEN
适用: 人, 小鼠, 大鼠, 犬, 马, Cow, 豚鼠, 兔, 斑马鱼
WB
宿主: 兔
Polyclonal
unconjugated
1 image
PSENEN
适用: 人, 小鼠, 大鼠
宿主: 兔
Monoclonal
Alexa Fluor 555
Recombinant Antibody
PSENEN
适用: 人, 小鼠, 大鼠
宿主: 兔
Monoclonal
Alexa Fluor 680
Recombinant Antibody
PSENEN
适用: 人, 小鼠, 大鼠
宿主: 兔
Monoclonal
Alexa Fluor 488
Recombinant Antibody
PSENEN
适用: 人, 小鼠, 大鼠
宿主: 兔
Monoclonal
Alexa Fluor 750
Recombinant Antibody
Latest Publications for our PEN2 抗体
: "Distribution and expression of Pen-2 in the central nervous system of APP/PS1 double transgenic mice." in: Acta biochimica et biophysica Sinica, Vol. 47, Issue 4, pp. 258-66, (2015) (PubMed).: "Functional reconstitution of gamma-secretase through coordinated expression of presenilin, nicastrin, Aph-1, and Pen-2." in: Journal of neuroscience research, Vol. 77, Issue 3, pp. 309-22, (2004) (PubMed).
: "PEN-2 and APH-1 coordinately regulate proteolytic processing of presenilin 1." in: The Journal of biological chemistry, Vol. 278, Issue 10, pp. 7850-4, (2003) (PubMed).
: "Membrane topology of gamma-secretase component PEN-2." in: The Journal of biological chemistry, Vol. 278, Issue 22, pp. 20117-23, (2003) (PubMed).
: "The role of presenilin cofactors in the gamma-secretase complex." in: Nature, Vol. 422, Issue 6930, pp. 438-41, (2003) (PubMed).
: "APH1, PEN2, and Nicastrin increase Abeta levels and gamma-secretase activity." in: Biochemical and biophysical research communications, Vol. 305, Issue 3, pp. 502-9, (2003) (PubMed).
: "aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation." in: Developmental cell, Vol. 3, Issue 1, pp. 85-97, (2002) (PubMed).
Aliases for PEN2 抗体
presenilin enhancer gamma-secretase subunit (PSENEN) 抗体presenilin enhancer 2 (PEN2) 抗体
presenilin enhancer 2 (Psenen) 抗体
presenilin enhancer gamma secretase subunit (Psenen) 抗体
Gamma-secretase subunit pen-2 (pen-2) 抗体
presenilin enhancer (pen-2) 抗体
presenilin enhancer gamma secretase subunit S homeolog (psenen.S) 抗体
presenilin enhancer gamma secretase subunit (psenen) 抗体
presenilin enhancer gamma-secretase subunit (Psenen) 抗体
1700023M09Rik 抗体
ACYPI006208 抗体
anon-AE003800.1 抗体
CG33198 抗体
Dmel\\CG33198 抗体
dPen-2 抗体
MSTP064 抗体
PEN-2 抗体
Pen-2 抗体
pen-2 抗体
PEN2 抗体
pen2 抗体
Psenen 抗体
psenen 抗体
RGD1312037 抗体
zgc:109727 抗体
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