(serpin Peptidase Inhibitor, Clade F (Alpha-2 Antiplasmin, Pigment Epithelium Derived Factor), Member 1 (SERPINF1))
The protein encoded by this gene is a member of the serpin family, although it does not display the serine protease inhibitory activity shown by many of the other serpin family members. The encoded protein is secreted and strongly inhibits angiogenesis. In addition, this protein is a neurotrophic factor involved in neuronal differentiation in retinoblastoma cells.[provided by RefSeq, Mar 2011].
Morales, Townsend, Malone, Ewersmann, Macy, Inder, Limbrick: "Alterations in protein regulators of neurodevelopment in the cerebrospinal fluid of infants with posthemorrhagic hydrocephalus of prematurity." in: Molecular & cellular proteomics : MCP, Vol. 11, Issue 6, pp. M111.011973, (2012) (PubMed).
Schoenborn, Heid, Vollmert, Lingenhel, Adams, Hopkins, Illig, Zimmermann, Zechner, Hunt, Kronenberg: "The ATGL gene is associated with free fatty acids, triglycerides, and type 2 diabetes." in: Diabetes, Vol. 55, Issue 5, pp. 1270-5, (2006) (PubMed).
Nagai, De Mol, Van Hoef, Verstreken, Collen: "Depletion of circulating alpha(2)-antiplasmin by intravenous plasmin or immunoneutralization reduces focal cerebral ischemic injury in the absence of arterial recanalization." in: Blood, Vol. 97, Issue 10, pp. 3086-92, (2001) (PubMed).
Spranger, Osterhoff, Reimann, Möhlig, Ristow, Francis, Cristofalo, Hammes, Smith, Boulton, Pfeiffer: "Loss of the antiangiogenic pigment epithelium-derived factor in patients with angiogenic eye disease." in: Diabetes, Vol. 50, Issue 12, pp. 2641-5, (2001) (PubMed).
Aliases for PEDF 抗体
serpin family F member 1 (SERPINF1) 抗体 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 (serpinf1) 抗体 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 L homeolog (serpinf1.L) 抗体 serpin family F member 1 (Serpinf1) 抗体 serine (or cysteine) peptidase inhibitor, clade F, member 1 (Serpinf1) 抗体 AI195227 抗体 Dmrs91 抗体 EPC-1 抗体 MGC82984 抗体 OI6 抗体 OI12 抗体 PEDF 抗体 Pedf 抗体 Pedfl 抗体 Sdf3 抗体 SERPINF1 抗体 zgc:92072 抗体