(phosphoprotein Enriched in Astrocytes 15 (PEA15))
This gene encodes a death effector domain-containing protein, which is a major phosphoprotein in astrocytes, and an endogenous substrate for protein kinase C. Studies using knockout mice suggest that this protein may protect astrocytes from TNF-induced apoptosis. This protein is also overexpressed in type 2 diabetes mellitus, where it may contribute to insulin resistance in glucose uptake. [provided by RefSeq, Sep 2011].
Kim, Kang: "PKC, AKT and ERK1/2-Mediated Modulations of PARP1, NF-κB and PEA15 Activities Distinctly Regulate Regional Specific Astroglial Responses Following Status Epilepticus." in: Frontiers in molecular neuroscience, Vol. 12, pp. 180, (2019) (PubMed).
Lv, Ma, Zhang, Zheng, Ma, Zhao, Lai, Shen, Wang, Ji: "Quantitative proteomics reveals that PEA15 regulates astroglial A? phagocytosis in an Alzheimer's disease mouse model." in: Journal of proteomics, Vol. 110C, pp. 45-58, (2014) (PubMed).
Aliases for PEA15 抗体
proliferation and apoptosis adaptor protein 15 (PEA15) 抗体 proliferation and apoptosis adaptor protein 15 (Pea15) 抗体 phosphoprotein enriched in astrocytes 15 (PEA15) 抗体 proliferation and apoptosis adaptor protein 15 L homeolog (pea15.L) 抗体 proliferation and apoptosis adaptor protein 15 (pea15) 抗体 Astrocytic phosphoprotein PEA-15 (pea15) 抗体 phosphoprotein enriched in astrocytes 15 (pea15) 抗体 DKFZp459O1410 抗体 HMAT1 抗体 HUMMAT1H 抗体 MAT1 抗体 MAT1H 抗体 PEA-15 抗体 PEA15 抗体 Pea15a 抗体 PED 抗体