This gene encodes a member of a family of proteins that possess a 100-amino acid PDZ domain at the N terminus and one to three LIM domains at the C-terminus. This family member functions as a scaffold protein that tethers protein kinases to the Z-disk in striated muscles. It is thought to function in cardiomyocyte expansion and in restraining postsynaptic growth of excitatory synapses. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012].
Li, Ponten, dos Remedios: "The interactome of LIM domain proteins: the contributions of LIM domain proteins to heart failure and heart development." in: Proteomics, Vol. 12, Issue 2, pp. 203-25, (2012) (PubMed).
Cheng, Kimura, Peter, Cui, Ouyang, Shen, Liu, Gu, Dalton, Evans, Knowlton, Peterson, Chen: "Loss of enigma homolog protein results in dilated cardiomyopathy." in: Circulation research, Vol. 107, Issue 3, pp. 348-56, (2010) (PubMed).