Pyruvate Dehydrogenase (Lipoamide) alpha 1 产品
(Pyruvate Dehydrogenase (Lipoamide) alpha 1 (PDHA1))
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The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle. The PDH complex is composed of multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). The E1 enzyme is a heterotetramer of two alpha and two beta subunits. This gene encodes the E1 alpha 1 subunit containing the E1 active site, and plays a key role in the function of the PDH complex. Mutations in this gene are associated with pyruvate dehydrogenase E1-alpha deficiency and X-linked Leigh syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2010].
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Featured Pyruvate Dehydrogenase (Lipoamide) alpha 1 Categories
Pyruvate Dehydrogenase (Lipoamide) alpha 1 抗体
High quality antibodies with extensive validation data.
Pyruvate Dehydrogenase (Lipoamide) alpha 1 ELISA试剂盒
Reliable ELISA kits for a wide range of species.
Pyruvate Dehydrogenase (Lipoamide) alpha 1 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended Pyruvate Dehydrogenase (Lipoamide) alpha 1 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (7)
Cat. No.
ABIN7432574
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, IHC, IF
Validations
- (6)
Cat. No.
ABIN7259915
Quantity
200 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC (p)
Validations
- (6)
Cat. No.
ABIN518747
Quantity
50 μg
Datasheet
Datasheet
Recommended Pyruvate Dehydrogenase (Lipoamide) alpha 1 ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6969793
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6959003
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6959004
Quantity
96 tests
Datasheet
Datasheet
Recommended Pyruvate Dehydrogenase (Lipoamide) alpha 1 蛋白
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Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1314518
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Insect Cells
Validations
- (1)
Cat. No.
ABIN3084868
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Mouse
Source
Insect Cells
Validations
- (1)
Cat. No.
ABIN3133856
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our Pyruvate Dehydrogenase (Lipoamide) alpha 1 Products
: "The novel function of tumor protein D54 in regulating pyruvate dehydrogenase and metformin cytotoxicity in breast cancer." in: Cancer & metabolism, Vol. 7, pp. 1, (2019) (PubMed).: "Early TCR Signaling Induces Rapid Aerobic Glycolysis Enabling Distinct Acute T Cell Effector Functions." in: Cell reports, Vol. 22, Issue 6, pp. 1509-1521, (2019) (PubMed).
: "ORP4L Extracts and Presents PIP2 from Plasma Membrane for PLCβ3 Catalysis: Targeting It Eradicates Leukemia Stem Cells." in: Cell reports, Vol. 26, Issue 8, pp. 2166-2177.e9, (2019) (PubMed).
: "Loss of GCN5L1 in cardiac cells limits mitochondrial respiratory capacity under hyperglycemic conditions." in: Physiological reports, Vol. 7, Issue 8, pp. e14054, (2019) (PubMed).
: "The protein acetylase GCN5L1 modulates hepatic fatty acid oxidation activity via acetylation of the mitochondrial β-oxidation enzyme HADHA." in: The Journal of biological chemistry, Vol. 293, Issue 46, pp. 17676-17684, (2018) (PubMed).
: "Alcohol inhibits T-cell glucose metabolism and hepatitis in ALDH2-deficient mice and humans: roles of acetaldehyde and glucocorticoids." in: Gut, (2018) (PubMed).
: "The mitochondrial calcium uniporter underlies metabolic fuel preference in skeletal muscle." in: JCI insight, Vol. 3, Issue 22, (2018) (PubMed).
: "MicroRNA-23a promotes colorectal cancer cell survival by targeting PDK4." in: Experimental cell research, Vol. 373, Issue 1-2, pp. 171-179, (2018) (PubMed).
: "MiR-494-3p regulates mitochondrial biogenesis and thermogenesis through PGC1-α signalling in beige adipocytes." in: Scientific reports, Vol. 8, Issue 1, pp. 15096, (2018) (PubMed).
: "Pathological consequences of MICU1 mutations on mitochondrial calcium signalling and bioenergetics." in: Biochimica et biophysica acta, Vol. 1864, Issue 6, pp. 1009-1017, (2017) (PubMed).
Synonyms and alternative names related to Pyruvate Dehydrogenase (Lipoamide) alpha 1
pyruvate dehydrogenase E1 alpha 1 subunit (PDHA1), pyruvate dehydrogenase E1 alpha 1 (Pdha1), pyruvate dehydrogenase E1 alpha 1 subunit (Pdha1), pyruvate dehydrogenase (lipoamide) alpha 1 (PDHA1), pyruvate dehydrogenase E1 alpha 1 subunit (pdha1), pyruvate dehydrogenase (lipoamide) alpha 1 pseudogene (LOC719277), 2-oxo acid dehydrogenase (VNG_RS07485), pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha (RR_RS04695), pyruvate dehydrogenase alpha subunit protein (pdhA1), pyruvate dehydrogenase (acetyl-transferring) protein, alpha subunit (pdhA1), precursor of dehydrogenase pyruvate dehydrogenase E1 component alpha subunit (PDHA1), pyruvate dehydrogenase (PDHA1), pyruvate dehydrogenase E1 alpha 1 subunit a (pdha1a), pyruvate dehydrogenase E1 alpha 1 subunit b (pdha1b), pyruvate dehydrogenase E1 component subunit alpha (NI36_RS05240), pyruvate dehydrogenase (lipoamide) alpha 1 S homeolog (pdha1.S), im:6895726, NI36_05250, PDHA, pdha, Pdha-1, pdha1, Pdha1, pdha1-a, pdha1-b, PDHCE1A, pdhce1a, PHE1A, phe1a, wu:fd18b01, wu:fo96f03, wu:fp73b04, zgc:73271, zgc:86692, zgc:92705Protein level used designations for Pyruvate Dehydrogenase (Lipoamide) alpha 1
- PDHE1-A type I
- pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial
- pyruvate dehydrogenase complex, E1-alpha polypeptide 1
- pyruvate dehydrogenase E1alpha subunit
- pyruvate dehydrogenase E1 alpha 1
- pyruvate dehydrogenase E1 component alpha subunit
- pyruvate dehydrogenase alpha 1
- pyruvate dehydrogenase (lipoamide) alpha 1
- PdhA1
- pyruvate dehydrogenase alpha subunit
- pyruvate dehydrogenase E1 component subunit alpha
- pyruvate dehydrogenase alpha subunit protein
- pyruvate dehydrogenase (acetyl-transferring) protein, alpha subunit
- precursor of dehydrogenase pyruvate dehydrogenase E1 component alpha subunit
- pyruvate dehydrogenase
- Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial
- pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial-like
- fp73b04
- pyruvate dehydrogenase (lipoamide) alpha 1 S homeolog
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