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PDE10A 产品

(phosphodiesterase 10A (PDE10A))
The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase family. It plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This protein can hydrolyze both cAMP and cGMP to the corresponding nucleoside 5' monophosphate, but has higher affinity for cAMP, and is more efficient with cAMP as substrate. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Dec 2011].

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Featured PDE10A Categories

PDE10A 抗体

High quality antibodies with extensive validation data.

PDE10A ELISA试剂盒

Reliable ELISA kits for a wide range of species.

PDE10A 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended PDE10A 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IHC
Validations
  • (1)
  • (3)
Cat. No. ABIN2728471
Quantity 0.1 mL
Datasheet Datasheet
Reactivity Human
Application WB, IHC, IP, ICC
Validations
  • (2)
Cat. No. ABIN7436099
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse
Application WB, ELISA, ICC, IF
Validations
  • (2)
Cat. No. ABIN6264085
Quantity 100 μL
Datasheet Datasheet

Recommended PDE10A ELISA试剂盒

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6969258
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6958527
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN456476
Quantity 96 tests
Datasheet Datasheet

Recommended PDE10A 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1314446
Quantity 10 μg
Datasheet Datasheet
Reactivity Mouse
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3136395
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3085910
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our PDE10A Products

Maréchal, Guillemette, Goupil, Blondin, Leclerc, Richard: "Cyclic nucleotide phosphodiesterases in human spermatozoa and seminal fluid: Presence of an active PDE10A in human spermatozoa." in: Biochimica et biophysica acta, Vol. 1861, Issue 2, pp. 147-156, (2017) (PubMed).

Goupil, Maréchal, El Hajj, Tremblay, Richard, Leclerc: "Identification and Localization of the Cyclic Nucleotide Phosphodiesterase 10A in Bovine Testis and Mature Spermatozoa." in: PLoS ONE, Vol. 11, Issue 8, pp. e0161035, (2016) (PubMed).

Li, Lee, Xi, Zhu, Gary, Ramírez-Alcántara, Gurpinar, Canzoneri, Fajardo, Sigler, Piazza, Chen, Andrews, Thomas, Lu, Li, Laan, Moyer, Russo, Eberhardt, Yet, Keeton, Grizzle, Piazza: "Phosphodiesterase 10A: a novel target for selective inhibition of colon tumor cell growth and β-catenin-dependent TCF transcriptional activity." in: Oncogene, Vol. 34, Issue 12, pp. 1499-509, (2015) (PubMed).

Harada, Suzuki, Miura, Hasui, Kamiguchi, Ishii, Taniguchi, Kuroita, Takano, Stepanov, Halldin, Kimura: "Characterization of the binding properties of T-773 as a PET radioligand for phosphodiesterase 10A." in: Nuclear medicine and biology, Vol. 42, Issue 2, pp. 146-54, (2015) (PubMed).

Sancesario, Morrone, DAngelo, Castelli, Ferrazzoli, Sica, Martorana, Sorge, Cavaliere, Bernardi, Giorgi: "Levodopa-induced dyskinesias are associated with transient down-regulation of cAMP and cGMP in the caudate-putamen of hemiparkinsonian rats: reduced synthesis or increased catabolism?" in: Neurochemistry international, Vol. 79, pp. 44-56, (2015) (PubMed).

Mango, Bonito-Oliva, Ledonne, Nisticò, Castelli, Giorgi, Sancesario, Fisone, Berretta, Mercuri: "Phosphodiesterase 10A controls D1-mediated facilitation of GABA release from striato-nigral projections under normal and dopamine-depleted conditions." in: Neuropharmacology, Vol. 76 Pt A, pp. 127-36, (2014) (PubMed).

Heine, Sygnecka, Scherf, Berndt, Egerland, Hage, Franke: "Phosphodiesterase 2 inhibitors promote axonal outgrowth in organotypic slice co-cultures." in: Neuro-Signals, Vol. 21, Issue 3-4, pp. 197-212, (2013) (PubMed).

Tian, Vroom, Ghofrani, Weissmann, Bieniek, Grimminger, Seeger, Schermuly, Pullamsetti: "Phosphodiesterase 10A upregulation contributes to pulmonary vascular remodeling." in: PLoS ONE, Vol. 6, Issue 4, pp. e18136, (2011) (PubMed).

Giorgi, Melchiorri, Nuccetelli, DAngelo, Martorana, Sorge, Castelli, Bernardi, Sancesario: "PDE10A and PDE10A-dependent cAMP catabolism are dysregulated oppositely in striatum and nucleus accumbens after lesion of midbrain dopamine neurons in rat: a key step in parkinsonism physiopathology." in: Neurobiology of disease, Vol. 43, Issue 1, pp. 293-303, (2011) (PubMed).

Ong, Gribble, Reimann, Lynch, Houslay, Baillie, Furman, Pyne: "The role of the PDE4D cAMP phosphodiesterase in the regulation of glucagon-like peptide-1 release." in: British journal of pharmacology, Vol. 157, Issue 4, pp. 633-44, (2009) (PubMed).

Synonyms and alternative names related to PDE10A

phosphodiesterase 10A (PDE10A), phosphodiesterase 10A (Pde10a), HSPDE10A, Pde10a3

Protein level used designations for PDE10A

  • cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
  • dJ416F21.1 (phosphodiesterase 10A)
  • phosphodiesterase 10A1 (PDE10A1)
  • PDE10A2 brain-specific isoform
  • dual-substrate cAMP and cGMP, cyclic nucleotide phosphodiesterase
  • testis-specific phosphodiesterase PDE10A2
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