p300 抗体
(E1A Binding Protein P300 (EP300))
This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer. [provided by RefSeq, Jul 2008].
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Latest Publications for our p300 抗体
: "Dynamic Acetylation of Phosphoenolpyruvate Carboxykinase Toggles Enzyme Activity between Gluconeogenic and Anaplerotic Reactions." in: Molecular cell, Vol. 71, Issue 5, pp. 718-732.e9, (2019) (PubMed).: "MLL4 Is Required to Maintain Broad H3K4me3 Peaks and Super-Enhancers at Tumor Suppressor Genes." in: Molecular cell, Vol. 70, Issue 5, pp. 825-841.e6, (2018) (PubMed).
: "Baicalin inhibits pressure overload-induced cardiac fibrosis through regulating AMPK/TGF-β/Smads signaling pathway." in: Archives of biochemistry and biophysics, Vol. 640, pp. 37-46, (2018) (PubMed).
: "Genome-wide analysis of HIF-2α chromatin binding sites under normoxia in human bronchial epithelial cells (BEAS-2B) suggests its diverse functions." in: Scientific reports, Vol. 6, pp. 29311, (2016) (PubMed).
: "PRDX2 and PRDX4 are negative regulators of hypoxia-inducible factors under conditions of prolonged hypoxia." in: Oncotarget, Vol. 7, Issue 6, pp. 6379-97, (2016) (PubMed).
: "A novel nuclear Src and p300 signaling axis controls migratory and invasive behavior in pancreatic cancer." in: Oncotarget, Vol. 7, Issue 6, pp. 7253-67, (2016) (PubMed).
: "The peroxisome proliferator-activated receptor γ agonist pioglitazone prevents NF-κB activation in cisplatin nephrotoxicity through the reduction of p65 acetylation via the AMPK-SIRT1/p300 pathway." in: Biochemical pharmacology, Vol. 101, pp. 100-11, (2016) (PubMed).
: "Assembly and interrogation of Alzheimer's disease genetic networks reveal novel regulators of progression." in: PLoS ONE, Vol. 10, Issue 3, pp. e0120352, (2015) (PubMed).
: "Structure of a biologically active estrogen receptor-coactivator complex on DNA." in: Molecular cell, Vol. 57, Issue 6, pp. 1047-58, (2015) (PubMed).
: "KLF4 mediates the link between TGF-β1-induced gene transcription and H3 acetylation in vascular smooth muscle cells." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 29, Issue 9, pp. 4059-70, (2015) (PubMed).
Aliases for p300 抗体
E1A binding protein p300 (EP300) 抗体histone acetyltransferase p300 (LOC446056) 抗体
E1A binding protein p300 (ep300) 抗体
E1A binding protein p300 (Ep300) 抗体
A430090G16 抗体
A730011L11 抗体
KAT3B 抗体
p300 抗体
p300 HAT 抗体
RSTS2 抗体
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