(Purinergic Receptor P2X, Ligand-Gated Ion Channel, 6 (P2RX6))
The protein encoded by this gene belongs to the family of P2X receptors, which are ATP-gated ion channels and mediate rapid and selective permeability to cations. This gene is predominantly expressed in skeletal muscle, and regulated by p53. The encoded protein is associated with VE-cadherin at the adherens junctions of human umbilical vein endothelial cells. Alternative splicing results in multiple transcript variants. A related pseudogene, which is also located on chromosome 22, has been identified. [provided by RefSeq, Apr 2009].
Collo, North, Kawashima, Merlo-Pich, Neidhart, Surprenant, Buell: "Cloning OF P2X5 and P2X6 receptors and the distribution and properties of an extended family of ATP-gated ion channels." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 16, Issue 8, pp. 2495-507, (1996) (PubMed).