p130 蛋白
(Retinoblastoma-Like 2 (p130) (RBL2))
Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor.
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3 results
RBL2
宿主: 人
宿主: HEK-293 Cells
Recombinant
> 80 % as determined by SDS-PAGE and Coomassie blue staining
AbP, STD
1 image
Aliases for p130 蛋白
retinoblastoma-like 2 (p130) (RBL2) 蛋白RB transcriptional corepressor like 2 (RBL2) 蛋白
related to retinoblastoma 2 (LOC541652) 蛋白
RB transcriptional corepressor like 2 (Rbl2) 蛋白
p130 蛋白
P130 蛋白
PRB2 蛋白
Rb2 蛋白
RBL2 蛋白
RBR-2 蛋白
RBR2 蛋白
RRB2a 蛋白
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