p130 抗体
(Retinoblastoma-Like 2 (p130) (RBL2))
Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor.
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68 results
RBL2
适用: 人, 大鼠, 小鼠, Cow, 犬, 马, 兔, 豚鼠, 斑马鱼, Pig
WB
宿主: 兔
Polyclonal
unconjugated
1 image
Rockland Original
Latest Publications for our p130 抗体
: "Sj7170, a unique dual-function peptide with a specific ?-chymotrypsin inhibitory activity and a potent tumor-activating effect from scorpion venom." in: The Journal of biological chemistry, Vol. 289, Issue 17, pp. 11667-80, (2014) (PubMed).: "A small molecule based on the pRb2/p130 spacer domain leads to inhibition of cdk2 activity, cell cycle arrest and tumor growth reduction in vivo." in: Oncogene, Vol. 26, Issue 13, pp. 1829-39, (2007) (PubMed).
: "From G0 to S phase: a view of the roles played by the retinoblastoma (Rb) family members in the Rb-E2F pathway." in: Journal of cellular biochemistry, Vol. 102, Issue 6, pp. 1400-4, (2007) (PubMed).
: "Frequent loss of pRb2/p130 in human ovarian carcinoma." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 10, Issue 9, pp. 3098-103, (2004) (PubMed).
: "Differential regulation of Rb family proteins and prohibitin during camptothecin-induced apoptosis." in: Oncogene, Vol. 21, Issue 29, pp. 4539-48, (2002) (PubMed).
: "Perturbation of SUMOlation enzyme Ubc9 by distinct domain within nucleoporin RanBP2/Nup358." in: The Journal of biological chemistry, Vol. 277, Issue 7, pp. 4755-63, (2002) (PubMed).
: "FGF signaling targets the pRb-related p107 and p130 proteins to induce chondrocyte growth arrest." in: The Journal of cell biology, Vol. 158, Issue 4, pp. 741-50, (2002) (PubMed).
: "The retinoblastoma family: twins or distant cousins?" in: Genome biology, Vol. 3, Issue 9, pp. reviews3012, (2002) (PubMed).
: "p107 and p130: versatile proteins with interesting pockets." in: Experimental cell research, Vol. 264, Issue 1, pp. 135-47, (2001) (PubMed).
: "The retinoblastoma-related gene, RB2, maps to human chromosome 16q12 and rat chromosome 19." in: Oncogene, Vol. 8, Issue 12, pp. 3465-8, (1993) (PubMed).
Aliases for p130 抗体
retinoblastoma-like 2 (p130) (RBL2) 抗体RB transcriptional corepressor like 2 (RBL2) 抗体
related to retinoblastoma 2 (LOC541652) 抗体
RB transcriptional corepressor like 2 (Rbl2) 抗体
p130 抗体
P130 抗体
PRB2 抗体
Rb2 抗体
RBL2 抗体
RBR-2 抗体
RBR2 抗体
RRB2a 抗体
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