This gene encodes a cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Alternatively spliced transcript variants encoding different isoforms have been described for this gene. These isoforms exhibit different expression pattern, and have different biochemical, as well as physiological properties (PMID:9054445). [provided by RefSeq, Aug 2011].
custom-made
PXN
宿主: 小鼠
宿主: Cell-free protein synthesis (CFPS)
Recombinant
approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC).
WB, SDS, ELISA
custom-made
PXN
宿主: 人
宿主: Cell-free protein synthesis (CFPS)
Recombinant
approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC).
WB, SDS, ELISA
Sharifi, Mowers, Drake, Collier, Chen, Zamora, Mui, Macleod: "Autophagy Promotes Focal Adhesion Disassembly and Cell Motility of Metastatic Tumor Cells through the Direct Interaction of Paxillin with LC3." in: Cell reports, Vol. 15, Issue 8, pp. 1660-72, (2016) (PubMed).
Wang, Wang, Downey, Plotnikov, McCulloch: "A ternary complex comprising FAK, PTPα and IP3 receptor 1 functionally engages focal adhesions and the endoplasmic reticulum to mediate IL-1-induced Ca2+ signalling in fibroblasts." in: The Biochemical journal, Vol. 473, Issue 4, pp. 397-410, (2016) (PubMed).
Wilson, Bradley, Shaw, Wagenmakers: "Paxillin and focal adhesion kinase colocalise in human skeletal muscle and its associated microvasculature." in: Histochemistry and cell biology, Vol. 142, Issue 3, pp. 245-56, (2014) (PubMed).