This gene encodes a member of the parvin family of actin-binding proteins, which play a role in cytoskeleton organization and cell adhesion. These proteins are associated with focal contacts and contain calponin homology domains that bind to actin filaments. This family member binds to alphaPIX and alpha-actinin, and it can inhibit the activity of integrin-linked kinase. This protein also functions in tumor suppression. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011].
Eslami, Miyaguchi, Mogushi, Watanabe, Okada, Shibuya, Mizushima, Miura, Tanaka: "PARVB overexpression increases cell migration capability and defines high risk for endophytic growth and metastasis in tongue squamous cell carcinoma." in: British journal of cancer, Vol. 112, Issue 2, pp. 338-44, (2015) (PubMed).
Wu, Ng, Chen, Chang, Chuang, Weng, Liao, Pang: "Expression of parvin-beta is a prognostic factor for patients with urothelial cell carcinoma of the upper urinary tract." in: British journal of cancer, Vol. 103, Issue 6, pp. 852-60, (2010) (PubMed).