(Poly (ADP-Ribose) Polymerase Family, Member 14 (PARP14))
Poly(ADP-ribosyl)ation is an immediate DNA damage-dependent posttranslational modification of histones and other nuclear proteins that contributes to the survival of injured proliferating cells. PARP14 belongs to the superfamily of enzymes that perform this modification (Ame et al., 2004 [PubMed 15273990]).[supplied by OMIM, Mar 2008].
Iansante, Choy, Fung, Liu, Chai, Dyson, Del Rio, DSantos, Williams, Chokshi, Anders, Bubici, Papa: "PARP14 promotes the Warburg effect in hepatocellular carcinoma by inhibiting JNK1-dependent PKM2 phosphorylation and activation." in: Nature communications, Vol. 6, pp. 7882, (2015) (PubMed).
Vyas, Chesarone-Cataldo, Todorova, Huang, Chang: "A systematic analysis of the PARP protein family identifies new functions critical for cell physiology." in: Nature communications, Vol. 4, pp. 2240, (2013) (PubMed).