PAK4 抗体
(P21-Activated Kinase 4 (PAK4))
PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. They serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK4 interacts specifically with the GTP-bound form of Cdc42Hs and weakly activates the JNK family of MAP kinases. PAK4 is a mediator of filopodia formation and may play a role in the reorganization of the actin cytoskeleton. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
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Latest Publications for our PAK4 抗体
: "p21-Activated Kinase 4 Signaling Promotes Japanese Encephalitis Virus-Mediated Inflammation in Astrocytes." in: Frontiers in cellular and infection microbiology, Vol. 7, pp. 271, (2018) (PubMed).: "Adenovirus Modulates Toll-Like Receptor 4 Signaling by Reprogramming ORP1L-VAP Protein Contacts for Cholesterol Transport from Endosomes to the Endoplasmic Reticulum." in: Journal of virology, Vol. 91, Issue 6, (2017) (PubMed).
: "p21-Activated kinase 4 predicts early recurrence and poor survival in patients with nonmetastatic clear cell renal cell carcinoma." in: Urologic oncology, Vol. 33, Issue 5, pp. 205.e13-21, (2015) (PubMed).
: "p21-Activated kinase 5 (Pak5) localizes to mitochondria and inhibits apoptosis by phosphorylating BAD." in: Molecular and cellular biology, Vol. 23, Issue 16, pp. 5526-39, (2003) (PubMed).
: "p21-activated protein kinase 4 (PAK4) interacts with the keratinocyte growth factor receptor and participates in keratinocyte growth factor-mediated inhibition of oxidant-induced cell death." in: The Journal of biological chemistry, Vol. 278, Issue 12, pp. 10374-80, (2003) (PubMed).
: "p21-activated kinases: three more join the Pak." in: The international journal of biochemistry & cell biology, Vol. 34, Issue 7, pp. 713-7, (2002) (PubMed).
: "Requirement for PAK4 in the anchorage-independent growth of human cancer cell lines." in: The Journal of biological chemistry, Vol. 277, Issue 1, pp. 550-8, (2002) (PubMed).
: "PAK4, a novel effector for Cdc42Hs, is implicated in the reorganization of the actin cytoskeleton and in the formation of filopodia." in: The EMBO journal, Vol. 17, Issue 22, pp. 6527-40, (1999) (PubMed).
: "PKB/Akt: connecting phosphoinositide 3-kinase to cell survival and beyond." in: Trends in biochemical sciences, Vol. 22, Issue 9, pp. 355-8, (1997) (PubMed).
: "Regulation of human leukocyte p21-activated kinases through G protein--coupled receptors." in: Science (New York, N.Y.), Vol. 269, Issue 5221, pp. 221-3, (1995) (PubMed).
Aliases for PAK4 抗体
p21 (RAC1) activated kinase 4 (PAK4) 抗体p21 protein (Cdc42/Rac)-activated kinase 4 (Pak4) 抗体
p21 (RAC1) activated kinase 4 (Pak4) 抗体
p21 protein (Cdc42/Rac)-activated kinase 4 (pak4) 抗体
5730488L07Rik 抗体
AW555722 抗体
im:5916170 抗体
mKIAA1142 抗体
wu:fd12b01 抗体
zgc:92014 抗体
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