This gene encodes a member of the homeodomain (HD) family. HD family proteins are helix-turn-helix transcription factors that play key roles in the specification of cell fates. This protein may function during brain development.
Metwalli, Abellán, Freixes, Pross, Desfilis, Medina: "Distinct Subdivisions in the Transition Between Telencephalon and Hypothalamus Produce Otp and Sim1 Cells for the Extended Amygdala in Sauropsids." in: Frontiers in neuroanatomy, Vol. 16, pp. 883537, (2022) (PubMed).