Osteoactivin 产品
(Osteoactivin (GPNMB))
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The protein encoded by this gene is a type I transmembrane glycoprotein which shows homology to the pMEL17 precursor, a melanocyte-specific protein. GPNMB shows expression in the lowly metastatic human melanoma cell lines and xenografts but does not show expression in the highly metastatic cell lines. GPNMB may be involved in growth delay and reduction of metastatic potential. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
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Featured Osteoactivin Categories
Osteoactivin 抗体
High quality antibodies with extensive validation data.
Osteoactivin ELISA试剂盒
Reliable ELISA kits for a wide range of species.
Osteoactivin 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended Osteoactivin 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro)
Validations
- (6)
- (2)
- (1)
Cat. No.
ABIN749093
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC
Validations
- (2)
- (6)
Cat. No.
ABIN1724859
Quantity
0.1 mg
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA
Validations
- (2)
- (2)
Cat. No.
ABIN523856
Quantity
100 μg
Datasheet
Datasheet
Recommended Osteoactivin ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6969089
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN1889404
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN2859337
Quantity
96 tests
Datasheet
Datasheet
Recommended Osteoactivin 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Mouse
Source
HEK-293 Cells
Validations
- (2)
Cat. No.
ABIN7274754
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (2)
Cat. No.
ABIN7274753
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1355562
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our Osteoactivin Products
: "The glycoprotein GPNMB attenuates astrocyte inflammatory responses through the CD44 receptor." in: Journal of neuroinflammation, Vol. 15, Issue 1, pp. 73, (2019) (PubMed).: "Osteoactivin regulates head and neck squamous cell carcinoma invasion by modulating matrix metalloproteases." in: Journal of cellular physiology, Vol. 233, Issue 1, pp. 409-421, (2017) (PubMed).
: "Osteoactivin (GPNMB) ectodomain protein promotes growth and invasive behavior of human lung cancer cells." in: Oncotarget, Vol. 7, Issue 12, pp. 13932-44, (2017) (PubMed).
: "Osteoactivin Promotes Migration of Oral Squamous Cell Carcinomas." in: Journal of cellular physiology, Vol. 231, Issue 8, pp. 1761-70, (2016) (PubMed).
: "Growth and repair factors, osteoactivin, matrix metalloproteinase and heat shock protein 72, increase with resolution of inflammation in musculotendinous tissues in a rat model of repetitive grasping." in: BMC musculoskeletal disorders, Vol. 17, pp. 34, (2016) (PubMed).
: "The LINK-A lncRNA activates normoxic HIF1α signalling in triple-negative breast cancer." in: Nature cell biology, Vol. 18, Issue 2, pp. 213-24, (2016) (PubMed).
: "Elevation of glycoprotein nonmetastatic melanoma protein B in type 1 Gaucher disease patients and mouse models." in: FEBS open bio, Vol. 6, Issue 9, pp. 902-13, (2016) (PubMed).
: "Differential expression of glycoprotein non-metastatic melanoma protein B (GPNMB) involved in trichostatin A-induced apoptosis in gastric cancer." in: International journal of clinical and experimental medicine, Vol. 7, Issue 12, pp. 4857-66, (2015) (PubMed).
: "Mutation in Osteoactivin Promotes Receptor Activator of NF?B Ligand (RANKL)-mediated Osteoclast Differentiation and Survival but Inhibits Osteoclast Function." in: The Journal of biological chemistry, Vol. 290, Issue 33, pp. 20128-46, (2015) (PubMed).
: "The potential role of the glycoprotein osteoactivin/glycoprotein nonmetastatic melanoma protein B in pancreatic cancer." in: Pancreas, Vol. 44, Issue 2, pp. 302-10, (2015) (PubMed).
Synonyms and alternative names related to Osteoactivin
glycoprotein nmb (Gpnmb), glycoprotein nmb (GPNMB), glycoprotein (transmembrane) nmb (Gpnmb), glycoprotein nmb L homeolog (gpnmb.L), DC-HIL, Dchil, HGFIN, ipd, NMBProtein level used designations for Osteoactivin
- osteoactivin
- transmembrane glycoprotein NMB
- glycoprotein NMB
- glycoprotein nmb-like protein
- transmembrane glycoprotein HGFIN
- dendritic cell-associated heparin sulfate proteoglycan-dependent integrin ligand
- dendritic cell-associated transmembrane protein
- iris pigment dispersion
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