This gene encodes an enzyme included in the 2', 5' oligoadenylate synthase family. This enzyme is induced by interferons and catalyzes the 2', 5' oligomers of adenosine in order to bind and activate RNase L. This enzyme family plays a significant role in the inhibition of cellular protein synthesis and viral infection resistance. [provided by RefSeq, Jul 2008].
Ibsen, Gad, Thavachelvam, Boesen, Desprès, Hartmann: "The 2'-5'-oligoadenylate synthetase 3 enzyme potently synthesizes the 2'-5'-oligoadenylates required for RNase L activation." in: Journal of virology, Vol. 88, Issue 24, pp. 14222-31, (2014) (PubMed).
Rebouillat, Hovnanian, David, Hovanessian, Williams: "Characterization of the gene encoding the 100-kDa form of human 2',5' oligoadenylate synthetase." in: Genomics, Vol. 70, Issue 2, pp. 232-40, (2001) (PubMed).
Ito, Shichijo, Tsuda, Ochi, Harashima, Saito, Itoh: "Molecular basis of T cell-mediated recognition of pancreatic cancer cells." in: Cancer research, Vol. 61, Issue 5, pp. 2038-46, (2001) (PubMed).