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Neuronally-directed effects of RXR activation in a mouse model of Alzheimer's disease
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Loss of RXRA is associated with Non-Small Cell Lung Cancer.
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Mice lacking the RXR-alpha receptor develop spontaneous melanoma following a single ultraviolet radiation exposure compared to mice with functional RXR-alpha receptor.
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The primary aim of the present study was to investigate the potential of Nur77 in Amyloid betainduced neuron apoptosis, and to evaluate the effect of RXRalpha nuclear export inhibition on neuronal apoptosis.
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These data suggest that RXRs may be of crucial importance in the mechanism of allergic asthma and that the novel RXR partial agonist NEt-4IB may be a promising candidate for the treatment of allergic airway inflammation and airway hyperresponsiveness in a model of allergic asthma.
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The study shows that FXR/RXR regulates Chop expression in a mouse model of steatohepatitis, providing novel insights into pathogenesis of this disorder.
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These results suggest a mechanism to establish RXR therapeutic targets with significance in neurodegeneration.
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The optimal PPARalpha/RXRalpha heterodimer binding sequence was WAWVTRGGBBAHRGKTYA. The single nucleotide substitution, which reduces binding of RXRalpha to DNA, attenuated PPARalpha-induced transcriptional activation, but this is not always true for PPARalpha.
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A change in the heterodimeric partner of Peroxisome Proliferator Activated Receptor-alpha from retinoid X receptor to Silent information regulator 1 is responsible for the impaired fatty acid metabolism and cardiac dysfunction in the failing heart.
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interaction of Wnt and RXR-alpha pathways in hepatocyte development and hepatocellular carcinoma
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a crucial role of RXRa in suppression of UVB-induced melanomas in the context of driver mutations such as activated CDK4(R24C/R24C) or oncogenic NRAS(Q61K) and altered expression of p53 and PTEN
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This uncovered a novel RXR-dependent innate immune regulatory pathway, suggesting that downregulation of RXR expression or RXR antagonist treatment benefits host antiviral response, whereas RXR agonist treatment may increase risk of viral infections.
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Data suggest that retinoic acid and GM-CSF-induced retinal dehydrogenase 2 (RALDH2) expression in dendritic cells requires cooperative binding of transcription factor Sp1 via the RA receptor/retinoid X receptor complex to the Aldh1a2 promoter.
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The expression and binding of RXRalpha to CYP3A genes in liver was sex-dependent and regulated by growth hormone secretion.
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The depletion of retinoic acid and the inhibition of RXRalpha function in hepatic tumors involve more complex mechanisms besides the activation of RAS/ERK pathway.
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These observations suggest that beta-apo-13-carotenone regulates RXRalpha transcriptional activity by inducing the formation of the "transcriptionally silent" RXRalpha tetramer.
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RXRs modulate post-UVR survival of dermal fibroblasts in a "non-cell autonomous" manner, underscoring their role in immune surveillance, while independently mediating post-UVR melanocyte survival in a "cell autonomous" manner
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Drupanin, a component of BGP, is a novel RXR agonist with slight PPARgamma agonistic activity.
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two models of cholestasis identify common and injury-specific roles for RXRalpha heterodimers and the functional relevance of an intact RXRalpha-DNA-binding domain in the hepatocytic adaptive cholestatic response
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Data indicate that all three retinoic acid receptor isoforms RARalha, RARbeta and RARgamma are expressed in naive CD8+ T cells, as well as CD8+ T cells activated for 48 or 72 h.
