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NUMBL 产品

(Numb Homolog (Drosophila)-Like (NUMBL))

Categories

Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF- kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the 'Lys-48'-linked polyubiquitination and degradation of TRAF6 in cortical neurons.

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Featured NUMBL Categories

NUMBL 抗体

High quality antibodies with extensive validation data.

NUMBL 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended NUMBL 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application ELISA, IHC, IF
Validations
  • (3)
Cat. No. ABIN7162085
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, ELISA, IHC, IF, ICC
Validations
  • (2)
Cat. No. ABIN6263771
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA
Validations
  • (1)
Cat. No. ABIN5539874
Quantity 100 μg
Datasheet Datasheet

Recommended NUMBL ELISA试剂盒

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN6231602
Quantity 96 tests
Datasheet Datasheet

Recommended NUMBL 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Tobacco (Nicotiana tabacum)
Validations
Cat. No. ABIN3094283
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Tobacco (Nicotiana tabacum)
Validations
Cat. No. ABIN3131350
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (1)
Cat. No. ABIN2727806
Quantity 20 μg
Datasheet Datasheet

Latest Publications for our NUMBL Products

Petersen, Zou, Hwang, Jan, Zhong: "Progenitor cell maintenance requires numb and numblike during mouse neurogenesis." in: Nature, Vol. 419, Issue 6910, pp. 929-34, (2002) (PubMed).

Synonyms and alternative names related to NUMBL

NUMB like, endocytic adaptor protein (NUMBL), numb homolog-like L homeolog (numbl.L), NUMB-like, endocytic adaptor protein (Numbl), numb-like (Numbl), cag3a, CAG3A, ctg3a, CTG3a, nbl, NBL, numb, numb-r, NUMB-R, numblike, NUMBLIKE, numbr, NUMBR, tnrc23, TNRC23

Protein level used designations for NUMBL

  • numb homolog-like
  • numb-like protein
  • numb-related protein
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