NSMCE2 产品
(E3 SUMO-Protein Ligase NSE2 (NSMCE2))
Categories
E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. Is not be required for the stability of the complex.The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components. Acts as a E3 ligase mediating SUMO attachment to various proteins such as SMC6L1 and TRAX, the shelterin complex subunits TERF1, TERF2, TINF2 and TERF2IP, and maybe the cohesin components RAD21 and STAG2. Required for recruitment of telomeres to PML nuclear bodies. SUMO protein-ligase activity is required for the prevention of DNA damage-induced apoptosis by facilitating DNA repair. Required for sister chromatid cohesion during prometaphase and mitotic progression (By similarity).
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Featured NSMCE2 Categories
Recommended NSMCE2 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IF
Validations
- (2)
- (2)
Cat. No.
ABIN531598
Quantity
50 μL
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, IHC
Validations
- (1)
Cat. No.
ABIN7150959
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Cow, Horse, Human, Pig, Rabbit
Application
WB, IHC, IHC (p)
Validations
- (1)
Cat. No.
ABIN6755380
Quantity
100 μL
Datasheet
Datasheet
Recommended NSMCE2 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Mouse
Source
HEK-293 Cells
Validations
- (3)
Cat. No.
ABIN7564788
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (3)
Cat. No.
ABIN7554766
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1313078
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our NSMCE2 Products
: "Non-SMC Element 2 (NSMCE2) of the SMC5/6 Complex Helps to Resolve Topological Stress." in: International journal of molecular sciences, Vol. 17, Issue 11, (2016) (PubMed).: "Effects of Nephrolithiasis on Serum DNase (Deoxyribonuclease I and II) Activity and E3 SUMO-Protein Ligase NSE2 (NSMCE2) in Malaysian Individuals." in: Biomedical and environmental sciences : BES, Vol. 28, Issue 9, pp. 660-5, (2015) (PubMed).
: "Expulsion of micronuclei containing amplified genes contributes to a decrease in double minute chromosomes from malignant tumor cells." in: International journal of cancer. Journal international du cancer, Vol. 134, Issue 6, pp. 1279-88, (2014) (PubMed).
: "De novo assembly of a PML nuclear subcompartment occurs through multiple pathways and induces telomere elongation." in: Journal of cell science, Vol. 124, Issue Pt 21, pp. 3603-18, (2011) (PubMed).
Synonyms and alternative names related to NSMCE2
NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase (Nsmce2), NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase (NSMCE2), NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase L homeolog (nsmce2.L), Smc5-6 complex non-SMC subunit 2 (nse2), 1110014D18Rik, AI661537, C8orf36, MMS21, Non-SMC element 2, NSE2, RGD1305156, ZMIZ7Protein level used designations for NSMCE2
- E3 SUMO-protein ligase NSE2
- MMS21 homolog
- non-structural maintenance of chromosomes element 2 homolog
- non-SMC element 2 homolog
- hMMS21
- methyl methanesulfonate sensitivity gene 21
- zinc finger, MIZ-type containing 7
- non-SMC element 2 homolog (MMS21, S. cerevisiae)
- Non-structural maintenance of chromosomes element 2
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