Acts as a specific receptor for the N-terminus of Nogo- B, a neural and cardiovascular regulator. Able to regulate vascular remodeling and angiogenesis. Its similarity with UPP synthase proteins suggests that it may act as a scaffold for the binding of isoprenyl lipids and/or prenylated proteins.
Rusak, Jablonska, Piotrowska, Grzegrzolka, Wojnar, Dziegiel: "Correlation of Expression of CHI3L1 and Nogo-A and their Role in Angiogenesis in Invasive Ductal Breast Carcinoma." in: Anticancer research, Vol. 39, Issue 5, pp. 2341-2350, (2019) (PubMed).
Miao, Gao, Harrison, Prendergast, Acevedo, Yu, Hu, Strittmatter, Sessa: "Identification of a receptor necessary for Nogo-B stimulated chemotaxis and morphogenesis of endothelial cells." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 103, Issue 29, pp. 10997-1002, (2006) (PubMed).