In yeast, over 200 protein and RNA cofactors are required for ribosome assembly, and these are generally conserved in eukaryotes. These factors orchestrate modification and cleavage of the initial 35S precursor rRNA transcript into the mature 18S, 5.8S, and 25S rRNAs, folding of the rRNA, and binding of ribosomal proteins and 5S RNA. Nob1 is involved in pre-rRNA processing. In a late cytoplasmic processing step, Nob1 cleaves a 20S rRNA intermediate at cleavage site D to produce the mature 18S rRNA (Lamanna and Karbstein, 2009 [PubMed 19706509]).[supplied by OMIM, Nov 2010].
Yin, Wang, Jiang, Wang, Wu, Liu: "Downregulation of NOB1 inhibits proliferation and promotes apoptosis in human oral squamous cell carcinoma." in: Oncology reports, Vol. 34, Issue 6, pp. 3077-87, (2015) (PubMed).
Tone, Toh-E: "Nob1p is required for biogenesis of the 26S proteasome and degraded upon its maturation in Saccharomyces cerevisiae." in: Genes & development, Vol. 16, Issue 24, pp. 3142-57, (2002) (PubMed).
Tone, Tanahashi, Tanaka, Fujimuro, Yokosawa, Toh-e: "Nob1p, a new essential protein, associates with the 26S proteasome of growing saccharomyces cerevisiae cells." in: Gene, Vol. 243, Issue 1-2, pp. 37-45, (2000) (PubMed).
Aliases for NOB1 抗体
NIN1/PSMD8 binding protein 1 homolog (NOB1) 抗体 RNA-binding NOB1-like protein (AT5G41190) 抗体 RNA-binding protein nob1 (EDI_130960) 抗体 RNA-binding protein NOB1 (CpipJ_CPIJ012739) 抗体 RNA-binding protein NOB1 (BDBG_01281) 抗体 RNA-binding protein NOB1 (PAAG_04204) 抗体 RNA-binding protein NOB1 (PITG_13300) 抗体 NIN1/RPN12 binding protein 1 homolog S homeolog (nob1.S) 抗体 NIN1/RPN12 binding protein 1 homolog (S. cerevisiae) (nob1) 抗体 NIN1/RPN12 binding protein 1 homolog (Nob1) 抗体 NIN1/PSMD8 binding protein 1 homolog (Nob1) 抗体 1700021I09Rik 抗体 ART-4 抗体 fc27e05 抗体 MEE6.26 抗体 MEE6_26 抗体 MST158 抗体 Nob1p 抗体 NOB1P 抗体 PSMD8BP1 抗体 Psmd8bp1 抗体 si:ch73-167i17.3 抗体 wu:fc27e05 抗体