Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Probably has a role in normal hematopoiesis by inhibition of granulocyte differentiation and induction of apoptosis.
Negroni, Venturelli, Tanno, Amendola, Ransac, Cesi, Calabretta, Raschellà: "Neuroblastoma specific effects of DR-nm23 and its mutant forms on differentiation and apoptosis." in: Cell death and differentiation, Vol. 7, Issue 9, pp. 843-50, (2000) (PubMed).