The protein encoded by this gene belongs to the NALP protein family. Members of the NALP protein family typically contain a NACHT domain, a NACHT-associated domain (NAD), a C-terminal leucine-rich repeat (LRR) region, and an N-terminal pyrin domain (PYD). This protein may play a regulatory role in the innate immune system as similar family members belong to the signal-induced multiprotein complex, the inflammasome, that activates the pro-inflammatory caspases, caspase-1 and caspase-5. [provided by RefSeq, Jul 2008].
Peng, Lin, Liu, Wang, Zhang: "NLRP9B protein is dispensable for oocyte maturation and early embryonic development in the mouse." in: The Journal of reproduction and development, Vol. 61, Issue 6, pp. 559-64, (2015) (PubMed).