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NLK.2 蛋白

(Nemo-Like Kinase, Gene 2 (NLK.2))
Negatively regulates Wnt/beta-catenin-signaling during development. Plays a role together with sox11 in neural induction during early embryogenesis. Involved in TGFbeta-mediated mesoderm induction in early embryos, acting downstream of map3k7/tak1 to phosphorylate stat3.1. Augments the rnf138/narf-directed ubiquitination and degradation of tcf/lef by enhancing the association of rnf138/narf and tcf/lef. Phosphorylates mef2a to play a role in anterior neural development, including eye formation.

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Synonyms and alternative names related to NLK.2

nemo-like kinase, gene 2 S homeolog (nlk.2.S), nlk, xnlk

Protein level used designations for NLK.2

  • Nemo-like kinase 2
  • Serine/threonine protein kinase NLK2
  • serine/threonine-protein kinase NLK2
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