Nicastrin 抗体
(Nicastrin (NCSTN))
This gene encodes a Type I transmembrane glycoprotein that is an integral component of the multimeric gamma-secretase complex. The encoded protein cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein, and may be a stabilizing cofactor required for gamma-secretase complex assembly. The cleavage of beta-amyloid precursor protein yields amyloid beta peptide, the main component of the neuritic plaque and the hallmark lesion in the brains of patients with Alzheimer's disease\; however, the nature of the encoded protein's role in Alzheimer's disease is not known for certain. Alternatively spliced transcript variants have been described, but their full-length nature has not been determined. [provided by RefSeq, Jul 2008].
Recommended next Filters:
91 results
Carrier-free
NCSTN
适用: 人, 小鼠, 大鼠
WB, ELISA, ICC, IF
宿主: 兔
Polyclonal
unconjugated
Latest Publications for our Nicastrin 抗体
: "NF-κB-regulated microRNA-574-5p underlies synaptic and cognitive impairment in response to atmospheric PM2.5 aspiration." in: Particle and fibre toxicology, Vol. 14, Issue 1, pp. 34, (2018) (PubMed).
: "Loss of nicastrin elicits an apoptotic phenotype in mouse embryos." in: Brain research, Vol. 1086, Issue 1, pp. 76-84, (2006) (PubMed).
: "Functional reconstitution of gamma-secretase through coordinated expression of presenilin, nicastrin, Aph-1, and Pen-2." in: Journal of neuroscience research, Vol. 77, Issue 3, pp. 309-22, (2004) (PubMed).
: "Intramembrane-cleaving proteases: controlled liberation of proteins and bioactive peptides." in: Trends in cell biology, Vol. 13, Issue 2, pp. 71-8, (2003) (PubMed).
: "APH1, PEN2, and Nicastrin increase Abeta levels and gamma-secretase activity." in: Biochemical and biophysical research communications, Vol. 305, Issue 3, pp. 502-9, (2003) (PubMed).
: "Positive and negative regulation of the gamma-secretase activity by nicastrin in a murine model." in: The Journal of biological chemistry, Vol. 278, Issue 35, pp. 33445-9, (2003) (PubMed).
: "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. ..." in: Genome research, Vol. 13, Issue 10, pp. 2265-70, (2003) (PubMed).
: "Loss of nicastrin elicits an apoptotic phenotype in mouse embryos." in: Brain research, Vol. 1086, Issue 1, pp. 76-84, (2006) (PubMed).
: "Functional reconstitution of gamma-secretase through coordinated expression of presenilin, nicastrin, Aph-1, and Pen-2." in: Journal of neuroscience research, Vol. 77, Issue 3, pp. 309-22, (2004) (PubMed).
: "Intramembrane-cleaving proteases: controlled liberation of proteins and bioactive peptides." in: Trends in cell biology, Vol. 13, Issue 2, pp. 71-8, (2003) (PubMed).
: "APH1, PEN2, and Nicastrin increase Abeta levels and gamma-secretase activity." in: Biochemical and biophysical research communications, Vol. 305, Issue 3, pp. 502-9, (2003) (PubMed).
: "Positive and negative regulation of the gamma-secretase activity by nicastrin in a murine model." in: The Journal of biological chemistry, Vol. 278, Issue 35, pp. 33445-9, (2003) (PubMed).
: "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. ..." in: Genome research, Vol. 13, Issue 10, pp. 2265-70, (2003) (PubMed).
Aliases for Nicastrin 抗体
nicastrin (NCSTN) 抗体nicastrin (nct) 抗体
nicastrin (ncstn) 抗体
nicastrin (CpipJ_CPIJ001617) 抗体
nicastrin (Ncstn) 抗体
Nicastrin (aph-2) 抗体
9430068N19Rik 抗体
AA727311 抗体
agro 抗体
APH2 抗体
Aph2 抗体
CG7012 抗体
D1Dau13e 抗体
DKFZp469O2418 抗体
Dmel\\CG7012 抗体
dNct 抗体
Kiaa0253 抗体
mKIAA0253 抗体
NCSTN 抗体
Nct 抗体
Nic 抗体
nic 抗体
S5A 抗体
ST96B 抗体
您还需要查找其他产品吗？
You are here:
