NHEJ1 抗体
(Nonhomologous End-Joining Factor 1 (NHEJ1))
Double-strand breaks in DNA result from genotoxic stresses and are among the most damaging of DNA lesions. This gene encodes a DNA repair factor essential for the nonhomologous end-joining pathway, which preferentially mediates repair of double-stranded breaks. Mutations in this gene cause different kinds of severe combined immunodeficiency disorders. [provided by RefSeq, Jul 2008].
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Latest Publications for our NHEJ1 抗体
: "PHF6 promotes non-homologous end joining and G2 checkpoint recovery." in: EMBO reports, Vol. 21, Issue 1, pp. e48460, (2020) (PubMed).: "XLF and APLF bind Ku80 at two remote sites to ensure DNA repair by non-homologous end joining." in: Nature structural & molecular biology, Vol. 25, Issue 10, pp. 971-980, (2018) (PubMed).
: "PAXX Is an Accessory c-NHEJ Factor that Associates with Ku70 and Has Overlapping Functions with XLF." in: Cell reports, Vol. 17, Issue 2, pp. 541-555, (2016) (PubMed).
: "Organization and dynamics of the nonhomologous end-joining machinery during DNA double-strand break repair." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 112, Issue 20, pp. E2575-84, (2015) (PubMed).
: "C-Terminal region of DNA ligase IV drives XRCC4/DNA ligase IV complex to chromatin." in: Biochemical and biophysical research communications, Vol. 439, Issue 2, pp. 173-8, (2013) (PubMed).
: "Clinical variability and novel mutations in the NHEJ1 gene in patients with a Nijmegen breakage syndrome-like phenotype." in: Human mutation, Vol. 31, Issue 9, pp. 1059-68, (2010) (PubMed).
: "Defective DNA repair and increased genomic instability in Cernunnos-XLF-deficient murine ES cells." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, Issue 11, pp. 4518-23, (2007) (PubMed).
: "Interplay between Cernunnos-XLF and nonhomologous end-joining proteins at DNA ends in the cell." in: The Journal of biological chemistry, Vol. 282, Issue 44, pp. 31937-43, (2007) (PubMed).
: "XLF interacts with the XRCC4-DNA ligase IV complex to promote DNA nonhomologous end-joining." in: Cell, Vol. 124, Issue 2, pp. 301-13, (2006) (PubMed).
Aliases for NHEJ1 抗体
non-homologous end joining factor 1 (NHEJ1) 抗体non-homologous end joining factor 1 S homeolog (nhej1.S) 抗体
non-homologous end joining factor 1 (nhej1) 抗体
solute carrier family 23 member 3 (SLC23A3) 抗体
nonhomologous end-joining factor 1 (nhej1) 抗体
nonhomologous end-joining factor 1 (Nhej1) 抗体
1700029B21Rik 抗体
cernunnos 抗体
NHEJ1 抗体
XLF 抗体
zgc:85657 抗体
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