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Human Tumor Necrosis Factor Protein expressed in Escherichia coli (E. coli) - ABIN1305134
Hogan, Vogel: Production of tumor necrosis factor by rIFN-gamma-primed C3H/HeJ (Lpsd) macrophages requires the presence of lipid A-associated proteins. in Journal of immunology (Baltimore, Md. : 1950) 1989
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Human Tumor Necrosis Factor Protein expressed in Escherichia coli (E. coli) - ABIN2003118
Black, Rauch, Kozlosky, Peschon, Slack, Wolfson, Castner, Stocking, Reddy, Srinivasan, Nelson, Boiani, Schooley, Gerhart, Davis, Fitzner, Johnson, Paxton, March, Cerretti: A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells. in Nature 1997
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Human Tumor Necrosis Factor Protein expressed in Escherichia coli (E. coli) - ABIN413820
Bhola, Simon: Determinism and divergence of apoptosis susceptibility in mammalian cells. in Journal of cell science 2009
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Rat (Rattus) Tumor Necrosis Factor Protein expressed in Escherichia coli (E. coli) - ABIN413826
Muehlbauer, Lima, Goldman, Jacobson, Rivera, Goldberg, Palladino, Casadevall, Brojatsch: Proteasome inhibitors prevent caspase-1-mediated disease in rodents challenged with anthrax lethal toxin. in The American journal of pathology 2010
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Mouse (Murine) Tumor Necrosis Factor Protein expressed in Escherichia coli (E. coli) - ABIN1305135
Jäättelä: Biologic activities and mechanisms of action of tumor necrosis factor-alpha/cachectin. in Laboratory investigation; a journal of technical methods and pathology 1991
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Human Tumor Necrosis Factor Protein expressed in Wheat germ - ABIN1323120
Ku, Kim, Bae: Piperlonguminine downregulates endothelial protein C receptor shedding in vitro and in vivo. in Inflammation 2014
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Human Tumor Necrosis Factor Protein expressed in Yeast (Pichia pastoris) - ABIN988275
Fritz, Radziwill: CNK1 promotes invasion of cancer cells through NF-kappaB-dependent signaling. in Molecular cancer research : MCR 2010
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Human Tumor Necrosis Factor Protein expressed in HEK-293 Cells - ABIN2712390
Adini, Adini, Bazinet, Watnick, Bielenberg, DAmato: Melanocyte pigmentation inversely correlates with MCP-1 production and angiogenesis-inducing potential. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2014
Human Tumor Necrosis Factor Protein expressed in Escherichia coli (E. coli) - ABIN5775829
Spatz, Eibl, Hink, Wolf, Fischer, Mayr, Schernthaner, Eibl: Impaired primary immune response in type-1 diabetes. Functional impairment at the level of APCs and T-cells. in Cellular immunology 2003
this study shows association of TNF-Alpha gene polymorphisms and susceptibility to hepatitis B virus infection in Egyptians
The TNF -1031T>C was singly associated with spondyloarthritis, and the haplotype C/G, resulting from -1031T>C/-308G>A combination, was significantly associated with a reduced risk of spondyloarthritis.
hese findings suggest that variations in IL6 (显示 IL6 蛋白), CXCL8 (显示 IL8 蛋白), and TNF are associated with the development and maintenance of mild persistent breast pain.
serum concentrations of IL-6 (显示 IL6 蛋白) and IL-10 (显示 IL10 蛋白) but not TNFa in patients with internal carotid artery stenosis allow to predict the progression of the degree of stenosis and the unfavorable change of atherosclerotic plaque morphology
Higher TNF-alpha levels were associated with post-stroke depression at 2 weeks in the presence of the -850T allele with a significant interaction term.
According to our data, TNF A -238G>A and IL-10 (显示 IL10 蛋白) -1082A>G, -819C>T and -592C>A may be associated with the development of prostate cancer and BPH (显示 GLI3 蛋白). We could also notice higher frequency of TNF A and IL-10 (显示 IL10 蛋白) risk haplotypes in smoker and alcohol user. Interestingly, IL-10 (显示 IL10 蛋白) risk haplotype was positively associated with aggressiveness of tumor.
In multivariate analysis, the IL1B (显示 IL1B 蛋白) rs16944 TT and TNF rs1799964 TC genotypes were significantly associated with intrauterine cytomegalovirus infection. Twenty-two out of 72 congenitally infected newborns had confirmed sensorineural hearing loss. Carriers of CT or TT genotype of CCL2 (显示 CCL2 蛋白) rs13900 had increased risk of hearing loss at birth and at 6 months of age.
TNF-alpha rs1800629 polymorphism confers susceptibility to osteoarthritis, especially among Asians. Larger studies with more diverse ethnic populations are needed to confirm these results.
The TNF-alpha gene may influence the pathogenesis of Polycystic ovary syndrome.
it can be concluded that molecular analysis of MBL (显示 MBL2 蛋白) rs1800450 AA genotype and TNF-alpha rs1800620 AA genotype is important in the early detection and treatment of T2DM with H. pylori cagA (显示 S100A8 蛋白)(+) infection.
This study demonstrated that TNF-alpha genetic deletion ameliorates the amyloid phenotype of the 5XFAD mouse model of AD. 5XFAD/TNF-alpha-/- mice exhibit significantly decreased amyloid deposition and reduced levels of AbetaPP-CTFs and amyloid-beta protein.
Data suggest that expression of Tnfa in adipocytes can be regulated by dietary fatty acids; here, polyunsaturated fatty acids regulate Tnfa expression via alteration in methylation of Tnfa promoter in rats fed polyunsaturated fatty acids (safflower oil versus coconut/olive oil) and in mouse adipocyte cell line incubated with polyunsaturated fatty acid (linoleic acid versus palmitic/oleic acids).
a precise mechanism for attenuation of HgCl2-induced liver dysfunction by dietary luteolin via regulating Sirt1 (显示 SIRT1 蛋白)/Nrf2 (显示 NFE2L2 蛋白)/TNF-alpha signaling pathway, and provide a foundation for further study of luteolin as a novel therapeutic agent against inorganic mercury poisoning.
a significant increase in plasma levels of IL-2 (显示 IL2 蛋白), IFN-g (显示 IFNG 蛋白) and TNF-a was revealed as assessed by ELISA. In conclusion, the results of the present study indicate that MENK has a cytotoxic effect on B16 melanoma cells in vitro and in vivo, and suggest a potential mechanism for these bioactivities.
findings suggest that PGRN (显示 GRN 蛋白) deficiency leads to excessive NF-kappaB (显示 NFKB1 蛋白) activation in microglia and elevated TNFalpha signaling, which in turn lead to hyperexcitability of medium spiny neurons and obsessive-compulsive behavior-like behavior.
findings highlight an epigenetic mechanism by which EZH2 (显示 EZH2 蛋白) integrates the multifaceted effects of TNFalpha signaling to promote the inflammatory response and apoptosis in colitis.
It is possible that JNK (显示 MAPK8 蛋白) and TNF-alpha commonly contribute to kidney damage by assembling a positive feedback cycle after crush syndrome, leading to increased apoptosis in the renal cortex. HMGB1 (显示 HMGB1 蛋白) from the muscle may be the trigger.
Excessive death of hepatocytes is a characteristic of liver injury. A new programmed cell death pathway has been described involving upstream death ligands such as TNF and downstream kinases such as RIPK1 (显示 RIPK1 蛋白).
Taken together, we have demonstrated a role for TNF in the development of classically activated macrophages in listeriosis
Inhibition of signaling stimulated by both TNF and IL1beta (显示 IL1B 蛋白) synergizes with NF-kappaB (显示 NFKB1 蛋白) inhibition in eliminating leukemic stem cells.
Data suggest that luteolytic factors (such as TNFa, interferon gamma (显示 IFNG 蛋白), and PGF2a) control expression of MMP1 (显示 MMP1 蛋白), other matrix metalloproteinases, and tissue inhibitors of metalloproteinase in cultured luteal cells.
These results suggest that polymorphism of the TNFalpha-824 A>G gene and mTNFalpha protein expression play an important role in the pathogenesis of enzootic bovine leukosis.
These results suggest that the endometrium might lower the TNF concentration in the blastocyst by (1) regulating TNF secretion into the uterine fluid and (2) inducing decreased TNF and TNFR2 (显示 TNFRSF1B 蛋白) mRNA transcription in the embryo.
There was a significant association between the proviral load and a low frequency of the G/G genotype of TNF-alpha at position -824.
SNP in the TNF-alpha gene affects immune function and reproductive performance in dairy cows.
Studied genotypic and expression profiling of partial TNF-alpha gene and its association with mastitis susceptibility in 129 crossbred cattle.
Messenger RNA and protein levels of prostaglandin (PG) E synthase (PGES (显示 PTGES 蛋白)), PGF2alpha receptor (PGFR), tumor necrosis factor-alpha (TNF) and Fas (显示 FAS 蛋白) were found to be higher in the corpus luteum of pregnancy than in corpus luteum of the cycle.
TNF-alpha up-regulates NaV1.7 (显示 SCN9A 蛋白) mRNA in both adrenal chromaffin cells and dorsal root ganglia (DRG) neurons, highlighting the peripheral nociceptive mechanism of TNF-alpha
These results provide evidence for a high prevalence of subclinical endometritis in repeat breeding cows as well as the involvement of TNFalpha and iNOS (显示 NOS2 蛋白) pathways in the regulation of this pathological condition.
Exposure to follicular fluid transiently increased the transcript levels of IL8 (显示 IL8 蛋白) and PTGS2 (显示 PTGS2 蛋白), and decreased the expression of SOD2 (显示 SOD2 蛋白), GPX3 (显示 GPX3 蛋白), DAB2 (显示 DAB2 蛋白), and NR3C1 (显示 NR3C1 蛋白). TNF and IL6 (显示 IL6 蛋白) levels were also decreased while those of NAMPT (显示 NAMPT 蛋白) were unaffected.
these findings provide the direct evidence that ADAM17 (显示 ADAM17 蛋白) cleaves porcine TNFalpha, which represents a new view for identifying potential therapeutic targets in anti-porcine reproductive and respiratory syndrome virus therapy
TMZ pretreatment effectively reduced the myocardial damage caused by CME via inhibiting the PDCD4 (显示 PDCD4 蛋白)/NF-kappaB (显示 NFKB1 蛋白)/ TNF-alpha pathway in cardiomyocytes.
TNF-alpha, secreted from activated Monocytes, mediates the downregulation of OTX2 (显示 OTX2 蛋白) and essential retinal pigment epithelium genes.
TNF-alpha induced MMP-13 (显示 MMP13 蛋白) expression by condylar cells might be involved in the degradation of the juvenile condyle.
TNF-alpha was able to promote theca interna cell proliferation. Our results suggest that TNF-alpha might play a role in hyperandrogenism, cortex thickness, and the increased ovary volume observed in polycystic ovaries.
This study showed that the -791(C-->T) mutation of the TNF-alpha gene could be considered an important potential genetic marker of enterotoxigenic Escherichia coli F18 (显示 MAMLD1 蛋白) resistance.
Both Nsp1beta and Nsp11 of porcine reproductive and respiratory syndrome virus were demonstrated to be responsible for the inhibitory effect on TNF-alpha production in pulmonary alveolar macrophages.
Study presents evidence demonstrating a single species of exotoxin ApxI, derived from A. pleuropneumoniae serotype 10, induces the expression and production of proinflammatory cytokines IL-1beta (显示 IL1B 蛋白), IL-8 (显示 IL8 蛋白) and TNF-alpha in porcine alveolar macrophages.
the role of miR (显示 MYLIP 蛋白)-181a in adipocyte differentiation by regulation of TNF-alpha
The NOS inhibitor, L-NMMA, significantly suppressed the combined effects of HT and CORM-2 on TNFalpha-triggered NFkappaBp65 phosphorylation as well as decreased cell viability.
Using in vivo, time-lapse imaging we show that as centrally-projecting pioneer axons from dorsal root ganglia (DRG (显示 COL4A1 蛋白)) enter the spinal cord, they initiate expression of the cytokine TNFalpha. This induction coincides with ensheathment of these axons by associated glia via a TNF receptor 2 (TNFR2 (显示 TNFRSF1B 蛋白))-mediated process.
The results reveal a crucial role for TNFalpha/TNFR2 (显示 TNFRSF1B 蛋白) axis in the protection of the skin against DUOX1 (显示 DUOX1 蛋白)-mediated oxidative stress.
proinflammatory cytokines IL-1 (显示 IL1A 蛋白)/TNFalpha trigger a novel antiviral mechanism involving AID to regulate host cell permissiveness to HBV infection.
TNF alpha is the first molecule identified that is produced by dying retinal neurons and is necessary to induce Muller glia to proliferate in the zebrafish retinal regeneration response.
The data suggest that Mycobacterium marinum SecA2 modulates adaptive immunity to promote granuloma stability, perhaps through induction of tumor necrosis factor alpha.
The data suggest that during infectious pancreatic necrosis virus infection, the expression of cytokines and metalloproteinases might be initiated through the TNFalpha/NF-kappaB (显示 NFKB1 蛋白)-mediated pathway.
Infectious pancreatic necrosis virus triggers two death pathways via up-stream induction of the pro-inflammatory cytokine TNFalpha.
Antisense knockdown of tnfa rescued hepatic steatosis and liver degeneration in dtp (显示 AHCY 蛋白) larvae, whereas the overexpression of tnfa and the hepatic phenotype were unchanged in dtp (显示 AHCY 蛋白) larvae.
TNF is not required for tuberculous granuloma formation, but maintains granuloma integrity indirectly by restricting mycobacterial growth within macrophages and preventing their necrosis.
The main proinflammatory effects of fish TNF-alpha are mediated through the activation of endothelial cells and point to the complexity of the evolution that has taken place in the regulation of innate immunity by cytokines.
These interactions result in the induction of the TNF signaling pathway, activation of apoptosis, and DNA-damage stress response.
Findings showed that both mucosal compartments harbor similar percentages of memory CD4 (显示 CD4 蛋白)(+) T cells and displayed comparable cytokine TNF-alpha responses to mitogenic stimulations prior to infection.
Primary role for IL-1beta (显示 IL1B 蛋白) and TNF-alpha in the triggering of preterm labor associated with inflammation or infection.
The results obtained showed that IL-6 (显示 IL6 蛋白) expression in adipose tissue biopsies derived from animals with equine metabolic syndrome was enhanced while TNF-alpha levels of both groups were comparable.
Data indicate that tumor necrosis factor-alpha production is closely related to ovarian steroid actions.
These results indicate that in equine corpus luteum, cytokines TNF, IFNG (显示 IFNG 蛋白) and FASL (显示 FASL 蛋白) regulate nitric oxide activity, via eNOS (显示 NOS3 蛋白) expression modulation.
These data show the presence of cytokines TNF and IFNG (显示 IFNG 蛋白), and their receptors, in the equine corpus luteum and indicate their potential involvement in regulation of luteal function.
The contribution of bronchial epithelium to airway inflammation, with focus on mRNA and protein expression of IL-6 (显示 IL6 蛋白), IL-10 (显示 IL10 蛋白) and TNF-alpha, in horses with recurrent airway obstruction during exacerbation and in remission is reported.
TUNEL staining was positively correlated with TNF-a protein expression. Our findings suggest that apoptosis can be induced in the vocal fold epithelium after 120min of modal intensity phonation. In contrast, shorter durations of vibration exposure do not result in apoptosis signaling.
Inflammatory factors such as TNF-alpha can stimulate MMP-2 (显示 MMP2 蛋白)/9 activity in corneal epithelium cells. This may be a potential manipulating mechanism of MMP expression in the pathogenesis of corneal diseases.
The JNK (显示 MAPK8 蛋白) pathway plays an important role in mechanical ventilation-stimulated TNF-alpha expression in alveolar macrophages, but the injury-stimulated IL-8 (显示 IL8 蛋白) expression may be regulated by other signaling pathways.
The TNFalpha-evoked Cl- current.
IL-1beta (显示 IL1B 蛋白) and TNF-alpha expression increases significantly during acute lung injury. Ambroxol combined with low-dose heparin inhibits teh release of IL-1beta (显示 IL1B 蛋白) and TNF-alpha.
Hypercapnia increased expression of TNFa and decreased expression of NFKB in acute lung injury models.
In the early stages of myocardial ischemia, bone marrow stem cells are mobilized and home to ischemic myocardium with a concomitant increase in expression of cytokines VEGF (显示 VEGFA 蛋白) and TNFalpha.
Ammonium perchlorate can increase gene expressions of types I, III collagens, TGF-beta(1 (显示 TGFB1 蛋白)) and TNF-alpha in lung of rabbits.
TNFalpha may either be directly or indirectly involved in vascular damage following an embolic stroke. Moreover, TNFalpha may mediate some of the detrimental effects of tPA (显示 PLAT 蛋白) on the vascular compartment
Data indicate that three single-nucleotide polymorphisms were identified in tumor necrosis factor-alpha (TNF-alpha) gene.
Macrophage- and neutrophil-derived TNF-alpha instructs skin langerhans cells to prime antiviral immune responses.
This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine.
, TNF, macrophage-derived
, TNF, monocyte-derived
, tumor necrosis factor ligand superfamily member 2
, tumor necrosis factor-alpha
, tumor necrosis factor (TNF superfamily, member 2)
, tumor necrosis factor alpha
, tumor necrosis factor
, tumor-necrosis factor
, tumour necrosis factor
, TNF alpha
, ATP-binding cassette, sub-family F (GCN20), member 1
, tumour necrosis factor alpha
, LPS-induced TNF-alpha factor homolog
, TNF-alpha factor
, lipid-induced TNF-alpha factor
, lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog
, small integral membrane protein of lysosome/late endosome
, tissue necrosis factor-alpha
, tumor necrosis factor, alpha
, Tumor necrosis factor ligand superfamily member 2
, TNF-alpha 1