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抗Rat (Rattus) MAP3K7 抗体:
抗Human MAP3K7 抗体:
抗Mouse (Murine) MAP3K7 抗体:
Human Polyclonal MAP3K7 Primary Antibody for DB - ABIN389721
Huang, Chiang, Hung, Hou: Targeting of TGF-β-activated protein kinase 1 inhibits chemokine (C-C motif) receptor 7 expression, tumor growth and metastasis in breast cancer. in Oncotarget 2015
The expression of IL-6 (显示 IL6 抗体) gene and protein was significantly induced by IL-17F (显示 IL17F 抗体). IL-17F (显示 IL17F 抗体) activated TAK1 and NF-kappaB (显示 NFKB1 抗体) in airway smooth muscle cells.
overexpression of miR (显示 MLXIP 抗体)-20a reduced colony formation and tumor growth. Furthermore, the data revealed that the function of miR (显示 MLXIP 抗体)-20a was probably exerted via targeting the TAK1 expression. Overexpression of miR (显示 MLXIP 抗体)-20a sensitizes the osteosarcoma cells to chemotherapeutic drugs.
TGFbeta (显示 TGFB1 抗体) and IL1beta (显示 IL1B 抗体) signaling interact at the SMAD2 (显示 SMAD2 抗体)/3 level in human primary MSC (显示 MSC 抗体). Down-stream TGFbeta (显示 TGFB1 抗体) target genes were repressed by IL1beta (显示 IL1B 抗体) independent of C-terminal SMAD2 (显示 SMAD2 抗体) phosphorylation. We demonstrate that SMAD2 (显示 SMAD2 抗体)/3 linker modifications are required for this interplay and identified TAK1 as a crucial mediator of IL1beta (显示 IL1B 抗体)-induced TGFbeta (显示 TGFB1 抗体) signal modulation.
increased TAK1 expression may be involved in the progression of gastric cancer.
miR (显示 MLXIP 抗体)-146a, serving as a tumor suppressor, may significantly promote GC cell apoptosis by inhibition of the NF-kappaB (显示 NFKB1 抗体) signaling pathway via targeting TAK1.
In conclusion, for the first time, we report that TRADD (显示 TRADD 抗体), TRAF2 (显示 TRAF2 抗体), RIP1 (显示 UQCRFS1 抗体) and TAK1 play a role in the regulating TNF-alpha (显示 TNF 抗体) signalling in human myometrium. These findings are of significance given the central role of TNF-alpha (显示 TNF 抗体) in the processes of human labour and delivery.
Rab1 (显示 RAB1A 抗体) is regulated by the host in a similar fashion, and that the innate immunity kinase TAK1 and Legionella effectors compete to regulate Rab1 (显示 RAB1A 抗体) by switch II modifications during infection.
nMet accelerated HCC (显示 FAM126A 抗体) tumorigenesis and metastasis via the activation of TAK1/NF-kappaB (显示 NFKB1 抗体) pathway.
TAK1 protein expression increased in cartilage tissue from spinal tuberculosis patients.
TAK1 regulates Nrf2 (显示 GABPA 抗体) through modulation of Keap-p62/SQSTM1 (显示 SQSTM1 抗体) interaction. This regulation is important for homeostatic antioxidant protection in the intestinal epithelium.
TAK1 (显示 NR2C2 抗体) inhibits HBV primarily at viral transcription level through activation of MAPK (显示 MAPK1 抗体)-JNK (显示 MAPK8 抗体) pathway.
we generated the transgenic mouse line with deletion of Tak1 and gain of function of Bmpr1a. This compound mutation leads to more severe craniofacial deformities than each single mutation.
Data indicate TNF receptor associated factor 6 (TRAF6 (显示 TRAF6 抗体)) as an essential molecular switch leading to cardiac hypertrophy in a transforming growth factor beta-activated kinase 1 (TAK1), -dependent manner.
It is a key regulator of the toll (显示 TLR4 抗体)-like receptor signaling pathway.
The conversion of Tak1 (显示 NR2C2 抗体)-B to Tak1 (显示 NR2C2 抗体)-A consistently led to significant accumulation of lipids in cultured AML12cells, as well as the dysregulation of several lipid metabolism-related genes in mouse liver. Different functional properties of the two isoforms may explain the conflicting functions previously reported for Tak1 (显示 NR2C2 抗体).
demonstrate the efficiency of ad--siRNA-TAK1 (显示 NR2C2 抗体) in controlling joint inflammation of Collagen-Induced Arthritis, which is associated with the suppression of the expression of pro-inflammatory cytokines and JNK (显示 MAPK8 抗体) activation.
These data, in addition to the fact that Map3k7 is upregulated in the sinus venous-the source of cells for the SAN-suggest that Map3k7 may be an endogenous regulator of the SAN fate
These results present a novel in vivo function, the negative role of TAK1 (显示 NR2C2 抗体) in marginal zone B-cell development that is likely associated with NF-kappaB2 activation.
Tnfr1 (显示 TNFRSF1A 抗体) deletion partially restored thymic and lung macrophages.
TAK1 (显示 NR2C2 抗体) is required for PPARgamma (显示 PPARG 抗体) transactivation and promotes PPARgamma (显示 PPARG 抗体) transcriptional activity synergistically with TAK1 binding protein 1 (TAB1 (显示 TAB1 抗体)).
The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2\; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.
mitogen-activated protein kinase kinase kinase 7
, TGF-beta-activated kinase TAK1
, TGF-beta activated kinase 1
, TGF-beta-activated kinase 1
, transforming growth factor-beta-activated kinase 1
, mitogen activated protein kinase kinase kinase 7
, transforming growth factor beta-activated kinase 1