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These findings unveil a novel function of ADD1 in maintaining spindle pole integrity through its interaction with TPX2.
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alpha-adducing SNPs were not associated with bone density among lead workers.
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These findings highlight that ADD1 methylation may have a contributing role in the pathogenesis of EH with varying implications for both genders.
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The ADD1 Gly460Trp gene polymorphism is significantly and independently associated with Essential Hypertension risk in a Caucasian population from Madeira Island.
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ZNF322A overexpression transcriptionally dysregulates genes involved in cell growth and motility therefore contributes to lung tumorigenesis and poor prognosis
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ADD1 rs4963 polymorphism showed an increased hypertension risk.
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This indicates that ADD1 G460W polymorphism could be an important factor in the pathophysiology of tinnitus.
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study shows that the a-adducin G460T polymorphism is associated with essential hypertension
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Study shows that ADD1-rs4963 conferred susceptibility to colorectal cancer (CRC) suggesting an association between ADD1 and CRC risk.
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The T allele of ADD1 is associated with essential hypertension in Asians.
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study of potential effects of interaction between DNA methylation of ADD1 promoter and ADD1 tagSNPs and environmental factors on essential hypertension (EH); results indicate ADD1 SNP rs4961 has a protective role in development of EH; interactions between alcohol consumption and DNA methylation of ADD1 gene promoter have a significant role in modifying EH susceptibility
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There were significant differences between the control group and pediatric hypertensive group in terms of ACE I/D (P<0.05) and AGT M235T (P<0.05) polymorphisms, but there were no differences in ADD Gly460Trp (P>0.05) polymorphism.
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A significant association was found between ADD1 gene G614T polymorphism and essential hypertension in Chinese patients. Further studies need to be done to confirm these findings in a large sample.
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When alpha-adducin complexes with sodium potassium ATPase in astrocytes, non-cell autonomous neurodegeneration is triggered.
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Data indicate that adducin promotes adhesion by regulating desmosomes and is part of a protective pathway in pemphigus.
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Phosphorylation of ADD1 at Ser12 and Ser355 by cyclin-dependent kinase 1 enables ADD1 to bind to myosin-X (Myo10).
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Fnnctional polymorphism in the phosphorylation site of ADD1 (rs4963) may influence the susceptibility of non-cardia gastric cancer.
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concentration of AST was inversely correlated with ADD1 CpG2-5 methylation levels in female controls. These observations may bring new hints to elaborate the pathogenesis of essential hypertension
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study is the first meta-analysis to evaluate the influences of ACE and ADD1 polymorphisms on blood pressure responses to hydrochlorothiazide to combine the inconsistent results of previous studies
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the rs4963 polymorphism within ADD1 gene is associated with essential hypertension in the Chinese population
