NEDD4-2 蛋白
(E3 ubiquitin-protein ligase NEDD4-like (NEDD4L))
This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein mediates the ubiquitination of multiple target substrates and plays a critical role in epithelial sodium transport by regulating the cell surface expression of the epithelial sodium channel, ENaC. Single nucleotide polymorphisms in this gene may be associated with essential hypertension. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012].
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NEDD4L
宿主: 小鼠
宿主: Cell-free protein synthesis (CFPS)
Recombinant
approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC).
ELISA, WB, SDS
NEDD4L
宿主: 人
宿主: 大肠杆菌（E. Coli）
Recombinant
Greater than 90 % as determined by SDS-PAGE.
ELISA, WB
Aliases for NEDD4-2 蛋白
neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase (NEDD4L) 蛋白NEDD4L (LOC776799) 蛋白
neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase S homeolog (nedd4l.S) 蛋白
neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase (Nedd4l) 蛋白
neural precursor cell expressed, developmentally down-regulated gene 4-like (Nedd4l) 蛋白
1300012C07Rik 蛋白
hNEDD4-2 蛋白
nedd4 蛋白
NEDD4 蛋白
NEDD4-2 蛋白
nedd4-2 蛋白
Nedd4-2 蛋白
NEDD4.2 蛋白
Nedd4b 蛋白
RSP5 蛋白
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